https://scholar.korea.ac.kr/handle/2021.sw.korea/457 2026-03-09T15:08:45Z https://scholar.korea.ac.kr/handle/2021.sw.korea/272529 Title: 조루증치료에 대한 비뇨기과 전문의의 임상치료 패턴에 관한 연구 Authors: MOON DU GEON 2103-11-29T00:00:00Z https://scholar.korea.ac.kr/handle/2021.sw.korea/160469 Title: 라켈 가정의학 Authors: Cho, Kyung-Hwan 2103-05-01T00:00:00Z https://scholar.korea.ac.kr/handle/2021.sw.korea/267270 Title: Novel human coronavirus in an infant patient with pneumonia, Republic of Korea Authors: Park, Kyungmin; Shin, Minsoo; Natasha, Augustine; Kim, Jongwoo; Noh, Juyoung; Kim, Seong-Gyu; Kim, Bohyeon; Park, Jieun; Seo, Ye-rin; Cho, Hee-Kyung; Byun, Kwan Soo; Kim, Ji Hoon; Lee, Young-Sun; Shim, Jung Ok; Kim, Won-Keun; Song, Jin-Won Abstract: Coronaviruses (CoVs) pose a significant threat to public health, causing a wide spectrum of clinical manifestations and outcomes. Beyond precipitating global outbreaks, Human CoVs (HCoVs) are frequently found among patients with respiratory infections. To date, limited attention has been directed towards alphacoronaviruses due to their low prevalence and fatality rates. Nasal swab and serum samples were collected from a paediatric patient, and an epidemiological survey was conducted. Retrospective surveillance investigated the molecular prevalence of CoV in 880 rodents collected in the Republic of Korea (ROK) from 2018 to 2022. Next-generation sequencing (NGS) and phylogenetic analyses characterized the novel HCoV and closely related CoVs harboured by Apodemus spp. On 15 December 2022, a 103-day-old infant was admitted with fever, cough, sputum production, and rhinorrhea, diagnosed with human parainfluenza virus 1 (HPIV-1) and rhinovirus co-infection. Elevated AST/ALT levels indicated transient liver dysfunction on the fourth day of hospitalization. Metagenomic NGS (mNGS) identified a novel HCoV in nasal swab and serum samples. Retrospective rodent surveillance and phylogenetic analyses showed the novel HCoV was closely related to alphacoronaviruses carried by Apodemus spp. in the ROK and China. This case highlights the potential of mNGS to identify emerging pathogens and raises awareness of possible extra-respiratory manifestations, such as transient liver dysfunction, associated with novel HCoVs. While the liver injury in this case may be attributable to the novel HCoV, further research is necessary to elucidate its clinical significance, epidemiological prevalence, and zoonotic origins. 2025-12-31T00:00:00Z https://scholar.korea.ac.kr/handle/2021.sw.korea/267847 Title: Impact of Multidrug-Resistant Bacterial Colonization on Clinical Characteristics, Antibiotic Treatment, and Clinical Outcomes of Hospital-Acquired Pneumonia Authors: Sim, Jae Kyeom; Min, Kyung Hoon; Yoo, Kwang Ha; Jeon, Kyeongman; Chang, Youjin; Hong, Sang-Bum; Baek, Ae-Rin; Park, Hye Kyeong; Moon, Jae Young; Lee, Hyun-Kyung; Cho, Woo Hyun; Kim, Jin Hyoung; Lee, Heung Bum; Kim, Changhwan; Bae, Soohyun; Gil, Hyun-Il; Shin, Beomsu; Oh, Jee Youn; Korean HAP VAP Study Grp Abstract: PurposeTo determine effects of colonization with multidrug-resistant bacteria (MDRB) in general wards on characteristics, treatment, and prognosis of hospital-acquired pneumonia (HAP).MethodsThis was a multicenter retrospective cohort study of patients with HAP admitted to 16 tertiary or university hospitals in Korea from July 2019 to December 2019. From the entire cohort, patients who developed pneumonia in general wards with known colonization status before the onset of pneumonia were included in this study. Patients were categorized into a colonization group and a non-colonization group according to MDRB colonization. Patients of the two groups were then compared.ResultsAmong a total of 400 patients, 63 were in the MDRB colonization group. HAP caused by MDR-Staphylococcus aureus or MDR-Pseudomonas aeruginosa was more common in the colonization group than in the non-colonization group (24.4% vs. 8.1%, P = 0.006 or 20.0% vs. 5.4%, P = 0.013, respectively). Colonization with certain bacteria was correlated with subsequent infection with the same bacteria. Carbapenem use (36.5% vs. 24.3%, P = 0.044) and appropriateness of initial antibiotics (50.8% vs. 12.8%) were higher in the colonization group than in the non-colonization group. Although in-hospital mortality was similar in the two groups (34.9% vs. 32.9%, P = 0.759), hospital length of stay was longer (38 days vs. 31 days, P = 0.009) and rate of discharge to home was lower (34.1% vs 59.7%, P = 0.002) in the colonization group.ConclusionsColonization with MDRB might influence characteristics and treatment of HAP. However, prognosis of HAP was not associated with MDRB colonization. 2025-12-01T00:00:00Z