Ten years of experience in the prevention of mother-to-child human immunodeficiency virus transmission in a university teaching hospital
DC Field | Value | Language |
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dc.contributor.author | Park, J.-W. | - |
dc.contributor.author | Yang, T.-W. | - |
dc.contributor.author | Kim, Y.-K. | - |
dc.contributor.author | Choi, B.-M. | - |
dc.contributor.author | Kim, H.-J. | - |
dc.contributor.author | Park, D.-W. | - |
dc.date.accessioned | 2021-09-05T15:51:31Z | - |
dc.date.available | 2021-09-05T15:51:31Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100681 | - |
dc.description.abstract | Purpose: Administration of antiretroviral drugs to mothers and infants significantly decreases mother-to-child human immunodeficiency virus (HIV) transmission; cesarean sections and discouraging breastfeeding further decreases this risk. The present study confirmed the HIV status of babies born to mothers infected with HIV and describes the characteristics of babies and mothers who received preventive treatment. Methods: This study retrospectively analyzed medical records of nine infants and their mothers positive for HIV who gave birth at Korea University Ansan Hospital, between June 1, 2003, and May 31, 2013. Maternal parameters, including HIV diagnosis date, CD4+ count, and HIV ribonucleic acid (RNA) copy number, were analyzed. Infant growth and development, HIV RNA copy number, and HIV antigen/antibody test results were analyzed. Results: Eight HIV-positive mothers delivered nine babies; all the infants received antiretroviral therapy. Three (37.5%) and five mothers (62.5%) were administered single- and multidrug therapy, respectively. Intravenous zidovudine was administered to four infants (50%) at birth. Breastfeeding was discouraged for all the infants. All the infants were negative for HIV, although two were lost to follow-up. Third trimester maternal viral copy numbers were less than 1,000 copies/mL with a median CD4+ count of 325/μL (92-729/μL). Among the nine infants, two were preterm (22.2%) and three had low birth weights (33.3%). Conclusion: This study concludes that prophylactic antiretroviral therapy, scheduled cesarean section, and prohibition of breastfeeding considerably decrease mother-to-child HIV transmission. Because the number of infants infected via mother-to-child transmission may be increasing, studies in additional regions using more variables are necessary. © 2014 by The Korean Pediatric Society. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Pediatric Society | - |
dc.subject | immunoglobulin G antibody | - |
dc.subject | lamivudine | - |
dc.subject | nelfinavir | - |
dc.subject | nonnucleoside reverse transcriptase inhibitor | - |
dc.subject | proteinase inhibitor | - |
dc.subject | zidovudine | - |
dc.subject | adult | - |
dc.subject | Apgar score | - |
dc.subject | article | - |
dc.subject | blood placenta barrier | - |
dc.subject | breast feeding | - |
dc.subject | CD4 lymphocyte count | - |
dc.subject | cesarean section | - |
dc.subject | clinical article | - |
dc.subject | female | - |
dc.subject | follow up | - |
dc.subject | gestational age | - |
dc.subject | heart ventricle septum defect | - |
dc.subject | highly active antiretroviral therapy | - |
dc.subject | human | - |
dc.subject | Human immunodeficiency virus infection | - |
dc.subject | low birth weight | - |
dc.subject | medical record review | - |
dc.subject | mixed infection | - |
dc.subject | polymerase chain reaction system | - |
dc.subject | premature labor | - |
dc.subject | prophylaxis | - |
dc.subject | respiratory distress syndrome | - |
dc.subject | retrospective study | - |
dc.subject | virus load | - |
dc.subject | virus transmission | - |
dc.subject | young adult | - |
dc.title | Ten years of experience in the prevention of mother-to-child human immunodeficiency virus transmission in a university teaching hospital | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Y.-K. | - |
dc.identifier.doi | 10.3345/kjp.2014.57.3.117 | - |
dc.identifier.scopusid | 2-s2.0-84896459469 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, v.57, no.3, pp.117 - 124 | - |
dc.relation.isPartOf | Korean Journal of Pediatrics | - |
dc.citation.title | Korean Journal of Pediatrics | - |
dc.citation.volume | 57 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 124 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001859069 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | immunoglobulin G antibody | - |
dc.subject.keywordPlus | lamivudine | - |
dc.subject.keywordPlus | nelfinavir | - |
dc.subject.keywordPlus | nonnucleoside reverse transcriptase inhibitor | - |
dc.subject.keywordPlus | proteinase inhibitor | - |
dc.subject.keywordPlus | zidovudine | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | Apgar score | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | blood placenta barrier | - |
dc.subject.keywordPlus | breast feeding | - |
dc.subject.keywordPlus | CD4 lymphocyte count | - |
dc.subject.keywordPlus | cesarean section | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | gestational age | - |
dc.subject.keywordPlus | heart ventricle septum defect | - |
dc.subject.keywordPlus | highly active antiretroviral therapy | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | Human immunodeficiency virus infection | - |
dc.subject.keywordPlus | low birth weight | - |
dc.subject.keywordPlus | medical record review | - |
dc.subject.keywordPlus | mixed infection | - |
dc.subject.keywordPlus | polymerase chain reaction system | - |
dc.subject.keywordPlus | premature labor | - |
dc.subject.keywordPlus | prophylaxis | - |
dc.subject.keywordPlus | respiratory distress syndrome | - |
dc.subject.keywordPlus | retrospective study | - |
dc.subject.keywordPlus | virus load | - |
dc.subject.keywordPlus | virus transmission | - |
dc.subject.keywordPlus | young adult | - |
dc.subject.keywordAuthor | Antiretroviral therapy | - |
dc.subject.keywordAuthor | HIV infections | - |
dc.subject.keywordAuthor | Postnatal care | - |
dc.subject.keywordAuthor | Prevention of HIV infections | - |
dc.subject.keywordAuthor | Vertical transmission of infectious disease | - |
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