The efficacy of tapering treatment with 0.1% tacrolimus ointment in adult patients with atopic dermatitis in Korea
DC Field | Value | Language |
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dc.contributor.author | Kye, H. | - |
dc.contributor.author | Seo, S.H. | - |
dc.contributor.author | Ahn, H.H. | - |
dc.contributor.author | Kye, Y.C. | - |
dc.date.accessioned | 2021-09-05T15:53:05Z | - |
dc.date.available | 2021-09-05T15:53:05Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100693 | - |
dc.description.abstract | Background: Tacrolimus ointment is a topical immunomodulator. Preliminary studies suggest that 0.1% tacrolimus is effective and has a proactive effect on atopic dermatitis with fewer complications than topical corticosteroids. Objective: The purpose of this study was to evaluate the efficacy and safety of tapering treatment with 0.1% tacrolimus ointment and its impact on quality of life in adult patients with atopic dermatitis in Korea. Korean adults with atopic dermatitis. Methods: A total of 53 patients aged 15 to 54 years with moderate to severe atopic dermatitis applied 0.1% tacrolimus ointment for 12 weeks. The 0.1% tacrolimus ointment was applied along with a topical corticosteroid once daily during the 2-week induction phase and twice daily during the 2-week transitional phase. During the 8-week maintenance phase, the corticosteroid was discontinued and the 0.1% tacrolimus ointment alone was applied twice daily for 2 weeks and twice weekly for 6 weeks. Efficacy and quality of life were evaluated by the SCORAD and the Dermatology Life Quality Index (DLQI), respectively. Results: SCORAD and DLQI values were significantly improved after 12 weeks of treatment. Symptoms were markedly improved after 2 weeks of applying the 0.1% tacrolimus ointment and the improvements were well maintained after tapering. Continuous improvement was observed throughout the study. Transient skin burning and itching occurred in about 43% of the patients, but gradually decreased in about 30% after continuous application. Conclusion: Tapering treatment with 0.1% tacrolimus ointment is safe and effective, and may replace the long-term use of topical corticosteroids, avoiding corticosteroid-associated adverse effects while maintaining clinical control and improving the quality of life of adult atopic dermatitis patients. | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.publisher | Korean Dermatological Association | - |
dc.title | The efficacy of tapering treatment with 0.1% tacrolimus ointment in adult patients with atopic dermatitis in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kye, Y.C. | - |
dc.identifier.scopusid | 2-s2.0-84903170719 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology, v.52, no.5, pp.314 - 319 | - |
dc.relation.isPartOf | Korean Journal of Dermatology | - |
dc.citation.title | Korean Journal of Dermatology | - |
dc.citation.volume | 52 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 314 | - |
dc.citation.endPage | 319 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001879611 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Quality of life | - |
dc.subject.keywordAuthor | Tacrolimus | - |
dc.subject.keywordAuthor | Treatment efficacy | - |
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