Tumor-specific immunity induced by cryoablation in a murine renal cell carcinoma model
DC Field | Value | Language |
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dc.contributor.author | Kim, H.K. | - |
dc.contributor.author | Pyun, J.H. | - |
dc.contributor.author | Cho, S. | - |
dc.contributor.author | Kang, S.G. | - |
dc.contributor.author | Lee, J.G. | - |
dc.contributor.author | Kim, J.J. | - |
dc.contributor.author | Cheon, J. | - |
dc.contributor.author | Park, H.S. | - |
dc.contributor.author | Kang, S.H. | - |
dc.date.accessioned | 2021-09-05T15:55:27Z | - |
dc.date.available | 2021-09-05T15:55:27Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2005-6737 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100709 | - |
dc.description.abstract | Purpose: To evaluate tumor-specific immunity and define the mechanisms involved in the cryoimmunologic response, we compared the tumor control efficacy and immunologic responses of cryoablation with those of surgical excision in a tumor rechallenge model.Materials and Methods: Sixty BALB/c mice with RENCA tumors that were generated in the left flank area underwent cryoablation or radical excision. The mice successfully treated were rechallenged with RENCA or an undifferentiated colon carcinoma cell line, CT26, in the contralateral right flank area. The recurrence rate after tumor rechallenge in each group was then observed. To assess the immunologic response of each treatment modality, fluorescent-activated cell sorting (FACS) analysis and a cytotoxicity assay using 51Cr release were performed.Results: After reinoculation of the RENCA cells, the rate of tumor growth was significantly higher in the surgical excision group than in the cryoablation group (94.4% vs. 11.1%, p=0.001). In the cryoablation group, the tumor growth rate was significantly increased after rechallenge of CT26 cells compared with RENCA (94.1% vs. 11.1%, p=0.001). The cryoablation group showed an elevated CD3, CD4, CD8 T, and natural killer cell count in the FACS analysis and also showed significantly increased cytotoxicity in the 51Cr release assay compared with the excision group.Conclusions: These results showed that cryoablation, compared to surgical resection, was more effective in preventing tumor growth after rechallenge with RENCA cells and that this response was tumor-specific, because the CT26 cells did not have the same effect. © The Korean Urological Association, 2014. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Urological Association | - |
dc.subject | liquid nitrogen | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | Article | - |
dc.subject | cancer control | - |
dc.subject | cancer recurrence | - |
dc.subject | CD4 lymphocyte count | - |
dc.subject | CD8+ T lymphocyte | - |
dc.subject | colorectal cancer cell line | - |
dc.subject | controlled study | - |
dc.subject | cryoablation | - |
dc.subject | cryoimmunologic response | - |
dc.subject | cytotoxicity assay | - |
dc.subject | fluorescence activated cell sorting | - |
dc.subject | histopathology | - |
dc.subject | immune response | - |
dc.subject | kidney carcinoma | - |
dc.subject | lymphocytotoxicity | - |
dc.subject | mouse | - |
dc.subject | Murinae | - |
dc.subject | natural killer cell | - |
dc.subject | nonhuman | - |
dc.subject | radical resection | - |
dc.subject | recurrence risk | - |
dc.subject | renal cell carcinoma cell line | - |
dc.subject | tumor growth | - |
dc.subject | tumor immunity | - |
dc.subject | animal | - |
dc.subject | Bagg albino mouse | - |
dc.subject | cancer transplantation | - |
dc.subject | Carcinoma, Renal Cell | - |
dc.subject | CD4+ T lymphocyte | - |
dc.subject | cell death | - |
dc.subject | cryosurgery | - |
dc.subject | cytotoxicity | - |
dc.subject | disease model | - |
dc.subject | immunology | - |
dc.subject | Kidney Neoplasms | - |
dc.subject | lymphocyte count | - |
dc.subject | pathology | - |
dc.subject | procedures | - |
dc.subject | tumor associated leukocyte | - |
dc.subject | tumor recurrence | - |
dc.subject | Animals | - |
dc.subject | Carcinoma, Renal Cell | - |
dc.subject | CD4-Positive T-Lymphocytes | - |
dc.subject | CD8-Positive T-Lymphocytes | - |
dc.subject | Cell Death | - |
dc.subject | Cryosurgery | - |
dc.subject | Cytotoxicity, Immunologic | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Kidney Neoplasms | - |
dc.subject | Lymphocyte Count | - |
dc.subject | Lymphocytes, Tumor-Infiltrating | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Neoplasm Recurrence, Local | - |
dc.subject | Neoplasm Transplantation | - |
dc.title | Tumor-specific immunity induced by cryoablation in a murine renal cell carcinoma model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, S.G. | - |
dc.contributor.affiliatedAuthor | Kim, J.J. | - |
dc.identifier.doi | 10.4111/kju.2014.55.12.834 | - |
dc.identifier.scopusid | 2-s2.0-84916605650 | - |
dc.identifier.bibliographicCitation | Korean Journal of Urology, v.55, no.12, pp.834 - 840 | - |
dc.relation.isPartOf | Korean Journal of Urology | - |
dc.citation.title | Korean Journal of Urology | - |
dc.citation.volume | 55 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 834 | - |
dc.citation.endPage | 840 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001935482 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | liquid nitrogen | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cancer control | - |
dc.subject.keywordPlus | cancer recurrence | - |
dc.subject.keywordPlus | CD4 lymphocyte count | - |
dc.subject.keywordPlus | CD8+ T lymphocyte | - |
dc.subject.keywordPlus | colorectal cancer cell line | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cryoablation | - |
dc.subject.keywordPlus | cryoimmunologic response | - |
dc.subject.keywordPlus | cytotoxicity assay | - |
dc.subject.keywordPlus | fluorescence activated cell sorting | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | immune response | - |
dc.subject.keywordPlus | kidney carcinoma | - |
dc.subject.keywordPlus | lymphocytotoxicity | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | Murinae | - |
dc.subject.keywordPlus | natural killer cell | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | radical resection | - |
dc.subject.keywordPlus | recurrence risk | - |
dc.subject.keywordPlus | renal cell carcinoma cell line | - |
dc.subject.keywordPlus | tumor growth | - |
dc.subject.keywordPlus | tumor immunity | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | Bagg albino mouse | - |
dc.subject.keywordPlus | cancer transplantation | - |
dc.subject.keywordPlus | Carcinoma, Renal Cell | - |
dc.subject.keywordPlus | CD4+ T lymphocyte | - |
dc.subject.keywordPlus | cell death | - |
dc.subject.keywordPlus | cryosurgery | - |
dc.subject.keywordPlus | cytotoxicity | - |
dc.subject.keywordPlus | disease model | - |
dc.subject.keywordPlus | immunology | - |
dc.subject.keywordPlus | Kidney Neoplasms | - |
dc.subject.keywordPlus | lymphocyte count | - |
dc.subject.keywordPlus | pathology | - |
dc.subject.keywordPlus | procedures | - |
dc.subject.keywordPlus | tumor associated leukocyte | - |
dc.subject.keywordPlus | tumor recurrence | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Carcinoma, Renal Cell | - |
dc.subject.keywordPlus | CD4-Positive T-Lymphocytes | - |
dc.subject.keywordPlus | CD8-Positive T-Lymphocytes | - |
dc.subject.keywordPlus | Cell Death | - |
dc.subject.keywordPlus | Cryosurgery | - |
dc.subject.keywordPlus | Cytotoxicity, Immunologic | - |
dc.subject.keywordPlus | Disease Models, Animal | - |
dc.subject.keywordPlus | Kidney Neoplasms | - |
dc.subject.keywordPlus | Lymphocyte Count | - |
dc.subject.keywordPlus | Lymphocytes, Tumor-Infiltrating | - |
dc.subject.keywordPlus | Mice, Inbred BALB C | - |
dc.subject.keywordPlus | Neoplasm Recurrence, Local | - |
dc.subject.keywordPlus | Neoplasm Transplantation | - |
dc.subject.keywordAuthor | Animal models | - |
dc.subject.keywordAuthor | Cryosurgery | - |
dc.subject.keywordAuthor | Immunity | - |
dc.subject.keywordAuthor | Renal cell carcinoma | - |
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