Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice
DC Field | Value | Language |
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dc.contributor.author | Hong, S. | - |
dc.contributor.author | Hwang, J. | - |
dc.contributor.author | Kim, J.Y. | - |
dc.contributor.author | Shin, K.S. | - |
dc.contributor.author | Kang, S.J. | - |
dc.date.accessioned | 2021-09-05T15:56:03Z | - |
dc.date.available | 2021-09-05T15:56:03Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100713 | - |
dc.description.abstract | Epidemiological studies have suggested an association between pesticide exposure and Parkinson's disease. In this study, we examined the neurotoxicity of an organochlorine pesticide, heptachlor, in vitro and in vivo. In cultured SH-SY5Y cells, heptachlor induced mitochondria-mediated apoptosis. When injected into mice intraperitoneally on a subchronic schedule, heptachlor induced selective loss of dopaminergic neurons in the substantia nigra pars compacta. In addition, the heptachlor injection induced gliosis of microglia and astrocytes selectively in the ventral midbrain area. When the general locomotor activities were monitored by open field test, the heptachlor injection did not induce any gross motor dysfunction. However, the compound induced Parkinsonism-like movement deficits when assessed by a gait and a pole test. These results suggest that heptachlor can induce Parkinson's disease-related neurotoxicities in vivo. Experimental & Molecular Medicine (2014) 46, e80; doi:10.1038/emm.2014.12; published online 28 February 2014. © 2014 KSBMB. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.subject | heptachlor | - |
dc.subject | pesticide | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal tissue | - |
dc.subject | apoptosis | - |
dc.subject | article | - |
dc.subject | astrocyte | - |
dc.subject | cell loss | - |
dc.subject | controlled study | - |
dc.subject | dopaminergic nerve cell | - |
dc.subject | experimental test | - |
dc.subject | gait | - |
dc.subject | gliosis | - |
dc.subject | in vitro study | - |
dc.subject | in vivo study | - |
dc.subject | locomotion | - |
dc.subject | male | - |
dc.subject | mesencephalon | - |
dc.subject | mouse | - |
dc.subject | neurotoxicity | - |
dc.subject | nonhuman | - |
dc.subject | open field test | - |
dc.subject | parkinsonism | - |
dc.subject | pole test | - |
dc.subject | substantia nigra pars compacta | - |
dc.subject | animal | - |
dc.subject | apoptosis | - |
dc.subject | cell culture | - |
dc.subject | chemically induced disorder | - |
dc.subject | drug effect | - |
dc.subject | human | - |
dc.subject | locomotion | - |
dc.subject | parkinsonism | - |
dc.subject | pathology | - |
dc.subject | pathophysiology | - |
dc.subject | substantia nigra | - |
dc.subject | toxicity and intoxication | - |
dc.subject | tumor cell line | - |
dc.subject | Animals | - |
dc.subject | Apoptosis | - |
dc.subject | Astrocytes | - |
dc.subject | Cell Line, Tumor | - |
dc.subject | Cells, Cultured | - |
dc.subject | Dopaminergic Neurons | - |
dc.subject | Gait | - |
dc.subject | Heptachlor | - |
dc.subject | Humans | - |
dc.subject | Locomotion | - |
dc.subject | Mice | - |
dc.subject | Neurotoxicity Syndromes | - |
dc.subject | Parkinsonian Disorders | - |
dc.subject | Pesticides | - |
dc.subject | Substantia Nigra | - |
dc.title | Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, J.Y. | - |
dc.identifier.doi | 10.1038/emm.2014.12 | - |
dc.identifier.scopusid | 2-s2.0-84896859979 | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, v.46, no.2 | - |
dc.relation.isPartOf | Experimental and Molecular Medicine | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.volume | 46 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001852243 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | heptachlor | - |
dc.subject.keywordPlus | pesticide | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | astrocyte | - |
dc.subject.keywordPlus | cell loss | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | dopaminergic nerve cell | - |
dc.subject.keywordPlus | experimental test | - |
dc.subject.keywordPlus | gait | - |
dc.subject.keywordPlus | gliosis | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | locomotion | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mesencephalon | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | neurotoxicity | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | open field test | - |
dc.subject.keywordPlus | parkinsonism | - |
dc.subject.keywordPlus | pole test | - |
dc.subject.keywordPlus | substantia nigra pars compacta | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | cell culture | - |
dc.subject.keywordPlus | chemically induced disorder | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | locomotion | - |
dc.subject.keywordPlus | parkinsonism | - |
dc.subject.keywordPlus | pathology | - |
dc.subject.keywordPlus | pathophysiology | - |
dc.subject.keywordPlus | substantia nigra | - |
dc.subject.keywordPlus | toxicity and intoxication | - |
dc.subject.keywordPlus | tumor cell line | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Apoptosis | - |
dc.subject.keywordPlus | Astrocytes | - |
dc.subject.keywordPlus | Cell Line, Tumor | - |
dc.subject.keywordPlus | Cells, Cultured | - |
dc.subject.keywordPlus | Dopaminergic Neurons | - |
dc.subject.keywordPlus | Gait | - |
dc.subject.keywordPlus | Heptachlor | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Locomotion | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Neurotoxicity Syndromes | - |
dc.subject.keywordPlus | Parkinsonian Disorders | - |
dc.subject.keywordPlus | Pesticides | - |
dc.subject.keywordPlus | Substantia Nigra | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Dopaminergic neuron | - |
dc.subject.keywordAuthor | Heptachlor | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | Organochlorine | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
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