Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tao, H. | - |
dc.contributor.author | Hwang, S.-W. | - |
dc.contributor.author | Marelli, B. | - |
dc.contributor.author | An, B. | - |
dc.contributor.author | Moreau, J.E. | - |
dc.contributor.author | Yang, M. | - |
dc.contributor.author | Brenckle, M.A. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Kaplan, D.L. | - |
dc.contributor.author | Rogers, J.A. | - |
dc.contributor.author | Omenetto, F.G. | - |
dc.date.accessioned | 2021-09-05T15:56:39Z | - |
dc.date.available | 2021-09-05T15:56:39Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100717 | - |
dc.description.abstract | A paradigm shift for implantable medical devices lies at the confluence between regenerative medicine, where materials remodel and integrate in the biological milieu, and technology, through the use of recently developed material platforms based on biomaterials and bioresorbable technologies such as optics and electronics. The union of materials and technology in this context enables a class of biomedical devices that can be optically or electronically functional and yet harmlessly degrade once their use is complete. We present here a fully degradable, remotely controlled, implantable therapeutic device operating in vivo to counter a Staphylococcus aureus infection that disappears once its function is complete. This class of device provides fully resorbable packaging and electronics that can be turned on remotely, after implantation, to provide the necessary thermal therapy or trigger drug delivery. Such externally controllable, resorbable devices not only obviate the need for secondary surgeries and retrieval, but also have extended utility as therapeutic devices that can be left behind at a surgical or suturing site, following intervention, and can be externally controlled to allow for infection management by either thermal treatment or by remote triggering of drug release when there is retardation of antibiotic diffusion, deep infections are present, or when systemic antibiotic treatment alone is insufficient due to the emergence of antibiotic-resistant strains. After completion of function, the device is safely resorbed into the body, within a programmable period. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | National Academy of Sciences | - |
dc.subject | ampicillin | - |
dc.subject | silk | - |
dc.subject | antiinfective agent | - |
dc.subject | biopolymer | - |
dc.subject | silk | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | antibiotic therapy | - |
dc.subject | Article | - |
dc.subject | bacterial count | - |
dc.subject | bacterium culture | - |
dc.subject | blood pressure regulation | - |
dc.subject | body temperature | - |
dc.subject | controlled study | - |
dc.subject | device safety | - |
dc.subject | drug delivery device | - |
dc.subject | drug delivery system | - |
dc.subject | drug release | - |
dc.subject | drug solubility | - |
dc.subject | electronics | - |
dc.subject | energy transfer | - |
dc.subject | glucose blood level | - |
dc.subject | microtechnology | - |
dc.subject | molecular weight | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | pH | - |
dc.subject | Staphylococcus infection | - |
dc.subject | animal | - |
dc.subject | Bacterial Infections | - |
dc.subject | Bagg albino mouse | - |
dc.subject | biodegradable implant | - |
dc.subject | chemistry | - |
dc.subject | devices | - |
dc.subject | drug delivery system | - |
dc.subject | electronics | - |
dc.subject | equipment design | - |
dc.subject | human | - |
dc.subject | radiofrequency radiation | - |
dc.subject | Staphylococcus aureus | - |
dc.subject | Staphylococcus infection | - |
dc.subject | temperature | - |
dc.subject | thermodynamics | - |
dc.subject | wireless communication | - |
dc.subject | Staphylococcus aureus | - |
dc.subject | Absorbable Implants | - |
dc.subject | Animals | - |
dc.subject | Anti-Infective Agents | - |
dc.subject | Bacterial Infections | - |
dc.subject | Biopolymers | - |
dc.subject | Drug Delivery Systems | - |
dc.subject | Electronics | - |
dc.subject | Equipment and Supplies | - |
dc.subject | Equipment Design | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Radio Waves | - |
dc.subject | Silk | - |
dc.subject | Staphylococcal Infections | - |
dc.subject | Staphylococcus aureus | - |
dc.subject | Temperature | - |
dc.subject | Thermodynamics | - |
dc.subject | Wireless Technology | - |
dc.title | Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, S.-W. | - |
dc.identifier.doi | 10.1073/pnas.1407743111 | - |
dc.identifier.scopusid | 2-s2.0-84917710446 | - |
dc.identifier.bibliographicCitation | Proceedings of the National Academy of Sciences of the United States of America, v.111, no.49, pp.17385 - 17389 | - |
dc.relation.isPartOf | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.citation.title | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.citation.volume | 111 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 17385 | - |
dc.citation.endPage | 17389 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ampicillin | - |
dc.subject.keywordPlus | silk | - |
dc.subject.keywordPlus | antiinfective agent | - |
dc.subject.keywordPlus | biopolymer | - |
dc.subject.keywordPlus | silk | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | antibiotic therapy | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | bacterial count | - |
dc.subject.keywordPlus | bacterium culture | - |
dc.subject.keywordPlus | blood pressure regulation | - |
dc.subject.keywordPlus | body temperature | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | device safety | - |
dc.subject.keywordPlus | drug delivery device | - |
dc.subject.keywordPlus | drug delivery system | - |
dc.subject.keywordPlus | drug release | - |
dc.subject.keywordPlus | drug solubility | - |
dc.subject.keywordPlus | electronics | - |
dc.subject.keywordPlus | energy transfer | - |
dc.subject.keywordPlus | glucose blood level | - |
dc.subject.keywordPlus | microtechnology | - |
dc.subject.keywordPlus | molecular weight | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | pH | - |
dc.subject.keywordPlus | Staphylococcus infection | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | Bacterial Infections | - |
dc.subject.keywordPlus | Bagg albino mouse | - |
dc.subject.keywordPlus | biodegradable implant | - |
dc.subject.keywordPlus | chemistry | - |
dc.subject.keywordPlus | devices | - |
dc.subject.keywordPlus | drug delivery system | - |
dc.subject.keywordPlus | electronics | - |
dc.subject.keywordPlus | equipment design | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | radiofrequency radiation | - |
dc.subject.keywordPlus | Staphylococcus aureus | - |
dc.subject.keywordPlus | Staphylococcus infection | - |
dc.subject.keywordPlus | temperature | - |
dc.subject.keywordPlus | thermodynamics | - |
dc.subject.keywordPlus | wireless communication | - |
dc.subject.keywordPlus | Staphylococcus aureus | - |
dc.subject.keywordPlus | Absorbable Implants | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Anti-Infective Agents | - |
dc.subject.keywordPlus | Bacterial Infections | - |
dc.subject.keywordPlus | Biopolymers | - |
dc.subject.keywordPlus | Drug Delivery Systems | - |
dc.subject.keywordPlus | Electronics | - |
dc.subject.keywordPlus | Equipment and Supplies | - |
dc.subject.keywordPlus | Equipment Design | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Inbred BALB C | - |
dc.subject.keywordPlus | Radio Waves | - |
dc.subject.keywordPlus | Silk | - |
dc.subject.keywordPlus | Staphylococcal Infections | - |
dc.subject.keywordPlus | Staphylococcus aureus | - |
dc.subject.keywordPlus | Temperature | - |
dc.subject.keywordPlus | Thermodynamics | - |
dc.subject.keywordPlus | Wireless Technology | - |
dc.subject.keywordAuthor | Biomaterials | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Resorbable electronics | - |
dc.subject.keywordAuthor | Silk | - |
dc.subject.keywordAuthor | Theranostics | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.