Differential Diagnosis of Patients with Inconclusive Parkinsonian Features Using [18F]FP-CIT PET/CT
DC Field | Value | Language |
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dc.contributor.author | Park, E. | - |
dc.contributor.author | Hwang, Y.M. | - |
dc.contributor.author | Lee, C.-N. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Oh, S.Y. | - |
dc.contributor.author | Kim, Y.C. | - |
dc.contributor.author | Choe, J.G. | - |
dc.contributor.author | Park, K.W. | - |
dc.date.accessioned | 2021-09-05T16:07:08Z | - |
dc.date.available | 2021-09-05T16:07:08Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100793 | - |
dc.description.abstract | Purpose: It is often difficult to differentiate parkinsonism, especially when patients show uncertain parkinsonian features. We investigated the usefulness of dopamine transporter (DAT) imaging for the differential diagnosis of inconclusive parkinsonism using [18F]FP-CIT PET. Methods: Twenty-four patients with inconclusive parkinsonian features at initial clinical evaluation and nine healthy controls were studied. Patients consisted of three subgroups: nine patients whose diagnoses were unclear concerning whether they had idiopathic Parkinson's disease or drug-induced parkinsonism ('PD/DIP'), nine patients who fulfilled neither the diagnostic criteria of PD nor of essential tremor ('PD/ET'), and six patients who were alleged to have either PD or atypical parkinsonian syndrome ('PD/APS'). Brain PET images were obtained 120 min after injection of 185 MBq [18F]FP-CIT. Imaging results were quantified and compared with follow-up clinical diagnoses. Results: Overall, 11 of 24 patients demonstrated abnormally decreased DAT availability on the PET scans, whereas 13 were normal. PET results could diagnose PD/DIP and PD/ET patients as having PD in six patients, DIP in seven, and ET in five; however, the diagnoses of all six PD/APS patients remained inconclusive. Among 15 patients who obtained a final follow-up diagnosis, the image-based diagnosis was congruent with the follow-up diagnosis in 11 patients. Four unsolved cases had normal DAT availability, but clinically progressed to PD during the follow-up period. Conclusion: [18F]FP-CIT PET imaging is useful in the differential diagnosis of patients with inconclusive parkinsonian features, except in patients who show atypical features or who eventually progress to PD. © 2013 Korean Society of Nuclear Medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | - |
dc.subject | dopamine transporter | - |
dc.subject | fp cit 18f | - |
dc.subject | radioligand | - |
dc.subject | unclassified drug | - |
dc.subject | adult | - |
dc.subject | aged | - |
dc.subject | article | - |
dc.subject | caudate nucleus | - |
dc.subject | clinical article | - |
dc.subject | computer assisted emission tomography | - |
dc.subject | controlled study | - |
dc.subject | differential diagnosis | - |
dc.subject | essential tremor | - |
dc.subject | female | - |
dc.subject | follow up | - |
dc.subject | human | - |
dc.subject | male | - |
dc.subject | parkinsonism | - |
dc.subject | priority journal | - |
dc.title | Differential Diagnosis of Patients with Inconclusive Parkinsonian Features Using [18F]FP-CIT PET/CT | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choe, J.G. | - |
dc.contributor.affiliatedAuthor | Park, K.W. | - |
dc.identifier.doi | 10.1007/s13139-013-0253-1 | - |
dc.identifier.scopusid | 2-s2.0-84901312086 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Molecular Imaging, v.48, no.2, pp.106 - 113 | - |
dc.relation.isPartOf | Nuclear Medicine and Molecular Imaging | - |
dc.citation.title | Nuclear Medicine and Molecular Imaging | - |
dc.citation.volume | 48 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 106 | - |
dc.citation.endPage | 113 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001882121 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | dopamine transporter | - |
dc.subject.keywordPlus | fp cit 18f | - |
dc.subject.keywordPlus | radioligand | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | caudate nucleus | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | computer assisted emission tomography | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | differential diagnosis | - |
dc.subject.keywordPlus | essential tremor | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | parkinsonism | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordAuthor | Dopamine transporter | - |
dc.subject.keywordAuthor | Inconclusive parkinsonian features | - |
dc.subject.keywordAuthor | Parkinsonism | - |
dc.subject.keywordAuthor | Positron emission tomography | - |
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