Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet
DC Field | Value | Language |
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dc.contributor.author | Min, H.S. | - |
dc.contributor.author | Kim, J.E. | - |
dc.contributor.author | Lee, M.H. | - |
dc.contributor.author | Song, H.K. | - |
dc.contributor.author | Lee, M.J. | - |
dc.contributor.author | Lee, J.E. | - |
dc.contributor.author | Kim, H.W. | - |
dc.contributor.author | Cha, J.J. | - |
dc.contributor.author | Hyun, Y.Y. | - |
dc.contributor.author | Han, J.Y. | - |
dc.contributor.author | Cha, D.R. | - |
dc.contributor.author | Kang, Y.S. | - |
dc.date.accessioned | 2021-09-05T16:10:37Z | - |
dc.date.available | 2021-09-05T16:10:37Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100819 | - |
dc.description.abstract | Background Obesity-related metabolic disorders are closely associated with inflammation induced by innate immunity. Toll-like receptors (TLRs) play a pivotal role in the innate immune system by activating proinflammatory signaling pathways. GIT27 (4,5-dihydro-3-phenyl-5-isoxasole acetic acid) is an active immunomodulatory agent that primarily targets macrophages and inhibits secretion of tumor necrosis factor α [as well as interleukin (IL)-1β, IL-10, and interferon γ]. However, the effect of TLR antagonist on kidney diseases has rarely been reported. We investigated whether the TLR antagonist GIT27 has beneficial effects on the progression of kidney disease in obese mice on a high-fat diet (HFD). Methods Six-week-old male C57BL/6 mice were divided into three groups: mice fed with normal chow diet (N=4); mice fed with a HFD (60% of total calories from fat, 5.5% from soybean oil, and 54.5% from lard, N=4); and GIT27-treated mice fed with a HFD (N=7). Results Glucose intolerance, oxidative stress, and lipid abnormalities in HFD mice were improved by GIT27 treatment. In addition, GIT27 treatment decreased the urinary excretion of albumin and protein in obesity-related kidney disease, urinary oxidative stress markers, and inflammatory cytokine levels. This treatment inhibited the expression of proinflammatory cytokines in the kidneys and adipose tissue, and improved extracellular matrix expansion and tubulointerstitial fibrosis in obesity-related kidney disease. Conclusion TLR inhibition by administering GIT27 improved metabolic parameters. GIT27 ameliorates abnormalities of lipid metabolism and may have renoprotective effects on obesity-related kidney disease through its anti-inflammatory properties. © 2014. The Korean Society of Nephrology. Published by Elsevier. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.subject | 4,5 dihydro 3 phenyl 5 isoxasole acetic acid | - |
dc.subject | cholesterol | - |
dc.subject | gamma interferon | - |
dc.subject | git 27 | - |
dc.subject | high density lipoprotein cholesterol | - |
dc.subject | immunoglobulin enhancer binding protein | - |
dc.subject | immunomodulating agent | - |
dc.subject | interleukin 2 | - |
dc.subject | low density lipoprotein cholesterol | - |
dc.subject | toll like receptor | - |
dc.subject | toll like receptor 4 | - |
dc.subject | tumor necrosis factor alpha | - |
dc.subject | unclassified drug | - |
dc.subject | adipose tissue | - |
dc.subject | albuminuria | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | antifibrotic activity | - |
dc.subject | antiinflammatory activity | - |
dc.subject | article | - |
dc.subject | comparative study | - |
dc.subject | controlled study | - |
dc.subject | disease course | - |
dc.subject | disorders of lipid metabolism | - |
dc.subject | drug activity | - |
dc.subject | drug effect | - |
dc.subject | extracellular matrix | - |
dc.subject | fibrosing alveolitis | - |
dc.subject | gene expression | - |
dc.subject | glucose intolerance | - |
dc.subject | immunohistochemistry | - |
dc.subject | kidney disease | - |
dc.subject | lipid blood level | - |
dc.subject | lipid diet | - |
dc.subject | lipid metabolism | - |
dc.subject | lipid peroxidation | - |
dc.subject | male | - |
dc.subject | metabolic disorder | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | obesity related kidney disease | - |
dc.subject | oxidative stress | - |
dc.subject | podocyte | - |
dc.subject | priority journal | - |
dc.subject | protein synthesis inhibition | - |
dc.subject | proteinuria | - |
dc.subject | renal protection | - |
dc.subject | signal transduction | - |
dc.title | Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, J.J. | - |
dc.contributor.affiliatedAuthor | Kang, Y.S. | - |
dc.identifier.doi | 10.1016/j.krcp.2013.11.002 | - |
dc.identifier.scopusid | 2-s2.0-84897442643 | - |
dc.identifier.bibliographicCitation | Kidney Research and Clinical Practice, v.33, no.1, pp.33 - 44 | - |
dc.relation.isPartOf | Kidney Research and Clinical Practice | - |
dc.citation.title | Kidney Research and Clinical Practice | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 44 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001867109 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | 4,5 dihydro 3 phenyl 5 isoxasole acetic acid | - |
dc.subject.keywordPlus | cholesterol | - |
dc.subject.keywordPlus | gamma interferon | - |
dc.subject.keywordPlus | git 27 | - |
dc.subject.keywordPlus | high density lipoprotein cholesterol | - |
dc.subject.keywordPlus | immunoglobulin enhancer binding protein | - |
dc.subject.keywordPlus | immunomodulating agent | - |
dc.subject.keywordPlus | interleukin 2 | - |
dc.subject.keywordPlus | low density lipoprotein cholesterol | - |
dc.subject.keywordPlus | toll like receptor | - |
dc.subject.keywordPlus | toll like receptor 4 | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | adipose tissue | - |
dc.subject.keywordPlus | albuminuria | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | antifibrotic activity | - |
dc.subject.keywordPlus | antiinflammatory activity | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | comparative study | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | disease course | - |
dc.subject.keywordPlus | disorders of lipid metabolism | - |
dc.subject.keywordPlus | drug activity | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | extracellular matrix | - |
dc.subject.keywordPlus | fibrosing alveolitis | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | glucose intolerance | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | kidney disease | - |
dc.subject.keywordPlus | lipid blood level | - |
dc.subject.keywordPlus | lipid diet | - |
dc.subject.keywordPlus | lipid metabolism | - |
dc.subject.keywordPlus | lipid peroxidation | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | metabolic disorder | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | obesity related kidney disease | - |
dc.subject.keywordPlus | oxidative stress | - |
dc.subject.keywordPlus | podocyte | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein synthesis inhibition | - |
dc.subject.keywordPlus | proteinuria | - |
dc.subject.keywordPlus | renal protection | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordAuthor | Kidney disease | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Toll-like receptors | - |
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