The use of everolimus to target carcinogenic pathways in a patient with renal cell carcinoma and tuberous sclerosis complex: A case report
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, H.S. | - |
dc.contributor.author | Kim, S.T. | - |
dc.contributor.author | Kang, S.H. | - |
dc.contributor.author | Sung, D.J. | - |
dc.contributor.author | Kim, C.H. | - |
dc.contributor.author | Shin, S.W. | - |
dc.contributor.author | Kim, Y.H. | - |
dc.contributor.author | Cho, W.Y. | - |
dc.contributor.author | Park, K.H. | - |
dc.date.accessioned | 2021-09-05T16:11:26Z | - |
dc.date.available | 2021-09-05T16:11:26Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1752-1947 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100825 | - |
dc.description.abstract | Introduction. An increased understanding of the genetic pathways involved in renal cell carcinoma has resulted in the development of various drugs that target relevant signaling cascades for the specific treatment of this disease. However, no validated predictive markers have been identified to guide the decision whether patients should receive vascular endothelial growth factor-targeted therapy or mammalian target of rapamycin-targeted therapy. We present what is, to the best of our knowledge, the first case of renal cell carcinoma in a patient with tuberous sclerosis complex who was successfully treated with everolimus. Case presentation. The patient was a 49-year-old Korean woman with tuberous sclerosis complex and recurrent renal cell carcinoma. The patient was treated with the tyrosine kinase inhibitor sunitinib followed by the mammalian target of rapamycin inhibitor everolimus. This treatment resulted in a prolonged response and significant clinical benefit. Notably, everolimus ameliorated the symptoms related not only to renal cell carcinoma but also to tuberous sclerosis complex. Conclusion: This case provides a rationale for the use of everolimus as first-line treatment for this specific patient population in order to target the correct pathway involved in carcinogenesis. © 2014 Kim et al.; licensee BioMed Central Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central Ltd. | - |
dc.subject | everolimus | - |
dc.subject | sunitinib | - |
dc.subject | adult | - |
dc.subject | article | - |
dc.subject | asymptomatic disease | - |
dc.subject | cancer recurrence | - |
dc.subject | cancer surgery | - |
dc.subject | case report | - |
dc.subject | clear cell carcinoma | - |
dc.subject | computer assisted tomography | - |
dc.subject | diarrhea | - |
dc.subject | drug dose reduction | - |
dc.subject | drug targeting | - |
dc.subject | eye examination | - |
dc.subject | female | - |
dc.subject | fibroadenoma | - |
dc.subject | folliculitis | - |
dc.subject | follow up | - |
dc.subject | hamartoma | - |
dc.subject | hand foot syndrome | - |
dc.subject | histopathology | - |
dc.subject | human | - |
dc.subject | human tissue | - |
dc.subject | hypothyroidism | - |
dc.subject | kidney biopsy | - |
dc.subject | kidney carcinoma | - |
dc.subject | lung cyst | - |
dc.subject | lymphangioleiomyomatosis | - |
dc.subject | middle aged | - |
dc.subject | nephrectomy | - |
dc.subject | nuclear magnetic resonance imaging | - |
dc.subject | pneumonia | - |
dc.subject | priority journal | - |
dc.subject | retinal hamartoma | - |
dc.subject | signal transduction | - |
dc.subject | spontaneous pneumothorax | - |
dc.subject | stomatitis | - |
dc.subject | subependymal giant cell astrocytoma | - |
dc.subject | thrombocytopenia | - |
dc.subject | treatment response | - |
dc.subject | tuberous sclerosis | - |
dc.title | The use of everolimus to target carcinogenic pathways in a patient with renal cell carcinoma and tuberous sclerosis complex: A case report | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, S.H. | - |
dc.contributor.affiliatedAuthor | Sung, D.J. | - |
dc.contributor.affiliatedAuthor | Kim, C.H. | - |
dc.contributor.affiliatedAuthor | Park, K.H. | - |
dc.identifier.doi | 10.1186/1752-1947-8-95 | - |
dc.identifier.scopusid | 2-s2.0-84898472792 | - |
dc.identifier.bibliographicCitation | Journal of Medical Case Reports, v.8, no.1 | - |
dc.relation.isPartOf | Journal of Medical Case Reports | - |
dc.citation.title | Journal of Medical Case Reports | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | spontaneous pneumothorax | - |
dc.subject.keywordPlus | stomatitis | - |
dc.subject.keywordPlus | subependymal giant cell astrocytoma | - |
dc.subject.keywordPlus | thrombocytopenia | - |
dc.subject.keywordPlus | treatment response | - |
dc.subject.keywordPlus | tuberous sclerosis | - |
dc.subject.keywordPlus | everolimus | - |
dc.subject.keywordPlus | sunitinib | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | asymptomatic disease | - |
dc.subject.keywordPlus | cancer recurrence | - |
dc.subject.keywordPlus | cancer surgery | - |
dc.subject.keywordPlus | case report | - |
dc.subject.keywordPlus | clear cell carcinoma | - |
dc.subject.keywordPlus | computer assisted tomography | - |
dc.subject.keywordPlus | diarrhea | - |
dc.subject.keywordPlus | drug dose reduction | - |
dc.subject.keywordPlus | drug targeting | - |
dc.subject.keywordPlus | eye examination | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | fibroadenoma | - |
dc.subject.keywordPlus | folliculitis | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | hamartoma | - |
dc.subject.keywordPlus | hand foot syndrome | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human tissue | - |
dc.subject.keywordPlus | hypothyroidism | - |
dc.subject.keywordPlus | kidney biopsy | - |
dc.subject.keywordPlus | kidney carcinoma | - |
dc.subject.keywordPlus | lung cyst | - |
dc.subject.keywordPlus | lymphangioleiomyomatosis | - |
dc.subject.keywordPlus | middle aged | - |
dc.subject.keywordPlus | nephrectomy | - |
dc.subject.keywordPlus | nuclear magnetic resonance imaging | - |
dc.subject.keywordPlus | pneumonia | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | retinal hamartoma | - |
dc.subject.keywordAuthor | Everolimus | - |
dc.subject.keywordAuthor | Mammalian target of rapamycin inhibitor | - |
dc.subject.keywordAuthor | Renal cell carcinoma | - |
dc.subject.keywordAuthor | Tuberous sclerosis complex | - |
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