Exposure to dichlorodiphenyltrichloroethane and the risk of breast cancer: A systematic review and meta-analysis
- Authors
- Park, J.-H.; Cha, E.S.; Ko, Y.; Hwang, M.-S.; Hong, J.-H.; Lee, W.J.
- Issue Date
- 2014
- Publisher
- Korean Disease Control and Prevention Agency
- Keywords
- Breast cancer; Dichlorodiphenyldichloroethylene; Meta-analysis; Pesticide exposure; Systematic review
- Citation
- Osong Public Health and Research Perspectives, v.5, no.2, pp.77 - 84
- Indexed
- SCOPUS
KCI
- Journal Title
- Osong Public Health and Research Perspectives
- Volume
- 5
- Number
- 2
- Start Page
- 77
- End Page
- 84
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/100845
- DOI
- 10.1016/j.phrp.2014.02.001
- ISSN
- 2210-9099
- Abstract
- Objectives: This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer. Methods: We reviewed the published literature on exposure to DDE and breast cancer risk to update a meta-analysis from 2004. The total of 35 studies included 16 hospital-based case-control studies, 11 population-based case-control studies, and 10 nested case-control studies identified through keyword searches in the PubMed and EMBASE databases. Results: The summary odds ratio (OR) for the identified studies was 1.03 (95% confidence interval 0.95-1.12) and the overall heterogeneity in the OR was observed (I2 = 40.9; p = 0.006). Subgroup meta-analyses indicated no significant association between exposure to DDE and breast cancer risk by the type of design, study years, biological specimen, and geographical region of the study, except from population-based case-control studies with estimated DDE levels in serum published in 1990s. Conclusion: Existing studies do not support the view that DDE increases the risk of breast cancer in humans. However, further studies incorporating more detailed information on DDT exposure and other potential risk factors for breast cancer are needed. © 2014.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.