Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yadav, Mukesh Kumar | - |
dc.contributor.author | Park, Seok-Won | - |
dc.contributor.author | Chae, Sung-Won | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.date.accessioned | 2021-09-05T16:52:15Z | - |
dc.date.available | 2021-09-05T16:52:15Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100987 | - |
dc.description.abstract | Pneumococcal colonization and disease is often associated with biofilm formation, in which the bacteria exhibit elevated resistance both to antibiotics and to host defense systems, often resulting in infections that are persistent and difficult to treat. We evaluated the effect of sinefungin, a nucleoside analogue of S-adenosylmethionine, on pneumococcal in vitro biofilm formation and in vivo colonization. Sinefungin is bacteriostatic to pneumococci and significantly decreased biofilm growth and inhibited proliferation and structure of actively growing biofilms but did not alter growth or the matrix structure of established biofilms. Sinefungin significantly reduced pneumococcal colonization in rat middle ear. The quorum sensing molecule (autoinducer-2) production was significantly reduced by 92% in sinefungin treated samples. The luxS, pfs, and speE genes were downregulated in biofilms grown in the presence of sinefungin. This study shows that sinefungin inhibits pneumococcal biofilm growth in vitro and colonization in vivo, decreases AI-2 production, and downregulates luxS, pfs, and speE gene expressions. Therefore, the S-adenosylmethionine (SAM) inhibitors could be used as lead compounds for the development of novel antibiofilm agents against pneumococci. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | QUORUM-SENSING SYSTEM | - |
dc.subject | IN-VITRO | - |
dc.subject | BACTERIAL BIOFILMS | - |
dc.subject | SIGNAL | - |
dc.subject | LUXS | - |
dc.subject | ADENOSYLHOMOCYSTEINE | - |
dc.subject | DNA | - |
dc.subject | METHYLTRANSFERASES | - |
dc.subject | COLONIZATION | - |
dc.subject | COMPETENCE | - |
dc.title | Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chae, Sung-Won | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.identifier.doi | 10.1155/2014/156987 | - |
dc.identifier.scopusid | 2-s2.0-84904087476 | - |
dc.identifier.wosid | 000338536600001 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2014 | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2014 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | QUORUM-SENSING SYSTEM | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BACTERIAL BIOFILMS | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.subject.keywordPlus | LUXS | - |
dc.subject.keywordPlus | ADENOSYLHOMOCYSTEINE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | METHYLTRANSFERASES | - |
dc.subject.keywordPlus | COLONIZATION | - |
dc.subject.keywordPlus | COMPETENCE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.