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Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging
- Issue Date
- 2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.50, no.23, pp.3044 - 3047
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 50
- Number
- 23
- Start Page
- 3044
- End Page
- 3047
- ISSN
- 1359-7345
- Abstract
- Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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