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A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Authors
Kim, TaeyoungJeon, Hyun MiLe, Hoa ThiKim, Tae WooKang, ChulhunKim, Jong Seung
Issue Date
2014
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.50, no.57, pp.7690 - 7693
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
50
Number
57
Start Page
7690
End Page
7693
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101033
DOI
10.1039/c4cc02878c
ISSN
1359-7345
Abstract
Herein, we present a fluorescent-peptide drug delivery system composed of biotin-naphthalimide-HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.
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