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A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum
- Authors
- Yang, Zhigang; He, Yanxia; Lee, Jae Hong; Chae, Weon-Sik; Ren, Wen Xiu; Lee, Joung Hae; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.50, no.79, pp.11672 - 11675
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 50
- Number
- 79
- Start Page
- 11672
- End Page
- 11675
- ISSN
- 1359-7345
- Abstract
- We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, epsilon) enhanced from 18.5 to 21.1.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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