Possible role of GABAergic depolarization in neocortical neurons in generating hyperexcitatory behaviors during emergence from sevoflurane anesthesia in the rat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Byung-Gun | - |
dc.contributor.author | Shen, Feng-Yan | - |
dc.contributor.author | Kim, Young-Beom | - |
dc.contributor.author | Kim, Woong Bin | - |
dc.contributor.author | Kim, Yoon Sik | - |
dc.contributor.author | Han, Hee Chul | - |
dc.contributor.author | Lee, Mi-Kyoung | - |
dc.contributor.author | Kong, Myoung-Hoon | - |
dc.contributor.author | Kim, Yang In | - |
dc.date.accessioned | 2021-09-05T17:02:14Z | - |
dc.date.available | 2021-09-05T17:02:14Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1759-0914 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101057 | - |
dc.description.abstract | Hyperexcitatory behaviors occurring after sevoflurane anesthesia are of serious clinical concern, but the underlying mechanism is unknown. These behaviors may result from the potentiation by sevoflurane of GABAergic depolarization/excitation in neocortical neurons, cells implicated in the genesis of consciousness and arousal. The current study sought to provide evidence for this hypothesis with rats, the neocortical neurons of which are known to respond to GABA (gamma-aminobutyric acid) with depolarization/excitation at early stages of development (i.e., until the second postnatal week) and with hyperpolarization/inhibition during adulthood. Employing behavioral tests and electrophysiological recordings in neocortical slice preparations, we found: (1) sevoflurane produced PAHBs (post-anesthetic hyperexcitatory behaviors) in postnatal day (P) 1-15 rats, whereas it failed to elicit PAHBs in P16 or older rats; (2) GABAergic PSPs (postsynaptic potentials) were depolarizing/excitatory in the neocortical neurons of P5 and P10 rats, whereas mostly hyperpolarizing/inhibitory in the cells of adult rats; (3) at P14-15, < 50% of rats had PAHBs and, in general, the cells of the animals with PAHBs exhibited strongly depolarizing GABAergic PSPs, whereas those without PAHBs showed hyperpolarizing or weakly depolarizing GABAergic PSPs; (4) bumetanide [inhibitor of the Cl- importer NKCC (Na (+) -K+ -2Cl(-)cotransporter)] treatment at P5 suppressed PAHBs and depolarizing GABAergic responses; and (5) sevoflurane at 1% (i. e., concentration < 1 minimum alveolar concentration) potentiated depolarizing GABAergic PSPs in the neurons of P5 and P10 rats and of P14-15 animals with PAHBs, evoking action potentials in >= 50% of these cells. On the basis of these results, we conclude that sevoflurane may produce PAHBs by potentiating GABAergic depolarization/excitation in neocortical neurons. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PORTLAND PRESS LTD | - |
dc.subject | TEMPORAL-LOBE EPILEPSY | - |
dc.subject | IN-VITRO | - |
dc.subject | THALAMIC CONTRIBUTIONS | - |
dc.subject | EXCITATORY ACTIONS | - |
dc.subject | HORMONE NEURONS | - |
dc.subject | DORSAL-HORN | - |
dc.subject | GABA | - |
dc.subject | CHILDREN | - |
dc.subject | PROPOFOL | - |
dc.subject | AGITATION | - |
dc.title | Possible role of GABAergic depolarization in neocortical neurons in generating hyperexcitatory behaviors during emergence from sevoflurane anesthesia in the rat | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Byung-Gun | - |
dc.contributor.affiliatedAuthor | Kim, Young-Beom | - |
dc.contributor.affiliatedAuthor | Han, Hee Chul | - |
dc.contributor.affiliatedAuthor | Lee, Mi-Kyoung | - |
dc.contributor.affiliatedAuthor | Kong, Myoung-Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Yang In | - |
dc.identifier.doi | 10.1042/AN20140004 | - |
dc.identifier.scopusid | 2-s2.0-84901920964 | - |
dc.identifier.wosid | 000334592200005 | - |
dc.identifier.bibliographicCitation | ASN NEURO, v.6, no.2 | - |
dc.relation.isPartOf | ASN NEURO | - |
dc.citation.title | ASN NEURO | - |
dc.citation.volume | 6 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | TEMPORAL-LOBE EPILEPSY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | THALAMIC CONTRIBUTIONS | - |
dc.subject.keywordPlus | EXCITATORY ACTIONS | - |
dc.subject.keywordPlus | HORMONE NEURONS | - |
dc.subject.keywordPlus | DORSAL-HORN | - |
dc.subject.keywordPlus | GABA | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.subject.keywordPlus | AGITATION | - |
dc.subject.keywordAuthor | emergence agitation | - |
dc.subject.keywordAuthor | GABA | - |
dc.subject.keywordAuthor | KCC2 | - |
dc.subject.keywordAuthor | neocortex | - |
dc.subject.keywordAuthor | NKCC1 | - |
dc.subject.keywordAuthor | sevoflurane | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.