DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Bun-Hee | - |
dc.contributor.author | Lee, Jun-Seok | - |
dc.contributor.author | Chai, Young Gyu | - |
dc.contributor.author | Ko, Kwang-Pil | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Han, Dal Mu Ri | - |
dc.contributor.author | Ji, Hong | - |
dc.contributor.author | Jang, Gyeong-Ho | - |
dc.contributor.author | Shin, Hye Eun | - |
dc.date.accessioned | 2021-09-05T17:05:30Z | - |
dc.date.available | 2021-09-05T17:05:30Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0302-282X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101079 | - |
dc.description.abstract | Background: Several polymorphisnns of the dopamine D-3 receptor (DRD3) gene are reported to be involved in the susceptibility to alcoholism. Although the DRD3 rs6280 (Ser9-Gly) polymorphism plays an important role in various psychiatric disorders, findings regarding the association between this single-nucleotide polymorphism (SNP) and alcohol dependence (AD) have been inconsistent. Therefore, the present study investigated the association between the DRD3 gene rs6280 polymorphism with AD and Lesch type I AD in Korean subjects. Methods: The DRD3 rs6280 SNP was genotyped in a case-control sample comprising 245 AD patients and 130 healthy controls (HCs). Alcohol Use Disorders Identification Test (AUDIT) scores were also compared relative to genotype in all of the participants. Results: This SNP was significantly associated with both AD overall (chi(2) = 10.09 and p = 0.001, and chi(2) = 10.60 and p = 0.005, for the recessive and additive models, respectively) and with Lesch type I AD (chi(2) = 11.70 and p(r) = 0.001, and chi(2) = 11.70 and p = 0.003, for the recessive and additive models, respectively). The allele frequency differed significantly (chi(2) = 8.45, p = 0.004) between Lesch type I AD and HC subjects. The AUDIT total (F = 6.56, p = 0.011), hazardous alcohol use (F = 7.12, p = 0.008), dependence symptoms (F = 5.10, p = 0.025), and harmful alcohol use (F = 4.83, p = 0.029) scores were significantly higher in those who did not possess the S allele (genotype GG) than in those who did (genotypes SS +/- SG). Conclusions: The findings of this study suggest that the DRD3 rs6280 polymorphism is associated with the development of both AD overall and Lesch type I AD in Koreans. (C) 2014 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | DOPAMINE D-3 RECEPTOR | - |
dc.subject | D3 RECEPTOR | - |
dc.subject | ENVIRONMENTAL CONTRIBUTIONS | - |
dc.subject | PSYCHIATRIC EPIDEMIOLOGY | - |
dc.subject | SEEKING BEHAVIOR | - |
dc.subject | NO ASSOCIATION | - |
dc.subject | ANTAGONIST | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | REINSTATEMENT | - |
dc.subject | HOMOZYGOSITY | - |
dc.title | DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Heon-Jeong | - |
dc.identifier.doi | 10.1159/000358062 | - |
dc.identifier.scopusid | 2-s2.0-84899613842 | - |
dc.identifier.wosid | 000337267300002 | - |
dc.identifier.bibliographicCitation | NEUROPSYCHOBIOLOGY, v.69, no.3, pp.140 - 146 | - |
dc.relation.isPartOf | NEUROPSYCHOBIOLOGY | - |
dc.citation.title | NEUROPSYCHOBIOLOGY | - |
dc.citation.volume | 69 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 140 | - |
dc.citation.endPage | 146 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalResearchArea | Psychology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychology | - |
dc.subject.keywordPlus | DOPAMINE D-3 RECEPTOR | - |
dc.subject.keywordPlus | D3 RECEPTOR | - |
dc.subject.keywordPlus | ENVIRONMENTAL CONTRIBUTIONS | - |
dc.subject.keywordPlus | PSYCHIATRIC EPIDEMIOLOGY | - |
dc.subject.keywordPlus | SEEKING BEHAVIOR | - |
dc.subject.keywordPlus | NO ASSOCIATION | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | REINSTATEMENT | - |
dc.subject.keywordPlus | HOMOZYGOSITY | - |
dc.subject.keywordAuthor | Alcohol dependence | - |
dc.subject.keywordAuthor | DRD3 gene | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Lesch type I | - |
dc.subject.keywordAuthor | Alcohol Use Disorders Identification Test | - |
dc.subject.keywordAuthor | Koreans | - |
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