Associations between TRAF1-C5 Gene Polymorphisms and Rheumatoid Arthritis: A Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T17:09:54Z | - |
dc.date.available | 2021-09-05T17:09:54Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0882-0139 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101108 | - |
dc.description.abstract | Objective: The aim of this study is to determine whether tumor necrosis factor receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in different populations. Methods: We conducted a meta-analysis of associations between the TRAF1-C5 polymorphisms and RA susceptibility. Results: A total of 24 comparative studies were included in this meta-analysis, including 22,682 patients with RA and 23,493 controls. The meta-analysis showed an association between the second allele of rs10818488 and RA in Europeans, but not in Asians (OR 1.229, 95% CI 1.094-1.381, p = 0.001; OR 1.060, 95% CI 0.930-1.335, p = 0.092). The meta-analysis also indicated an association between the second allele of rs3761847 and RA in Europeans, but not in Asians (OR 1.156, 95% CI 1.006-1.327, p = 0.041; OR 1.049, 95% CI 0.952-1.156, p = 0.333). The meta-analysis revealed an association between the second allele of the rs2900180 and rs10760130 polymorphisms and RA risk in Europeans (OR 1.224, 95% CI 1.065-1.405, p = 0.004; OR 1.072, 95% CI 1.002-1.147, p = 0.042). Conclusions: This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | HAN CHINESE POPULATION | - |
dc.subject | SUSCEPTIBILITY LOCI | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | WIDE ASSOCIATION | - |
dc.subject | TRAF1/C5 | - |
dc.subject | RISK | - |
dc.subject | VARIANTS | - |
dc.subject | STAT4 | - |
dc.title | Associations between TRAF1-C5 Gene Polymorphisms and Rheumatoid Arthritis: A Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3109/08820139.2013.837917 | - |
dc.identifier.scopusid | 2-s2.0-84893423258 | - |
dc.identifier.wosid | 000330710100001 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGICAL INVESTIGATIONS, v.43, no.2, pp.97 - 112 | - |
dc.relation.isPartOf | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.title | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.volume | 43 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 97 | - |
dc.citation.endPage | 112 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | HAN CHINESE POPULATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY LOCI | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | WIDE ASSOCIATION | - |
dc.subject.keywordPlus | TRAF1/C5 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | STAT4 | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | TRAF1-C5 | - |
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