Intratumoral phenotypic heterogeneity as an encourager of cancer invasion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Yoojin | - |
dc.contributor.author | Han, Sewoon | - |
dc.contributor.author | Chung, Euiheon | - |
dc.contributor.author | Chung, Seok | - |
dc.date.accessioned | 2021-09-05T17:17:05Z | - |
dc.date.available | 2021-09-05T17:17:05Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1757-9694 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101158 | - |
dc.description.abstract | We present a novel in vitro breast tumor model to mimic intratumoral phenotypic heterogeneity based on a microfluidic system incorporating ECM scaffolds capable of providing a physiologically relevant tumor microenvironment. To study the regulation of invasive potentials by intratumoral subpopulation conditions, we developed heterogeneous cancer cell subpopulations by co-culturing two breast cancer cell types with distinct phenotypes, specifically, highly invasive and epithelial-like cancer cells. Our results indicate that intratumoral phenotypic heterogeneity acts as an encourager of cancer cell invasion through a 3D matrix depending on the neighboring ECM, with highly invasive cancer cells acting as the 'leader' and epithelial-like cancer cells as the 'follower', therefore enhancing the metastatic potential. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | TUMOR HETEROGENEITY | - |
dc.subject | BREAST-CANCER | - |
dc.subject | MICROENVIRONMENT | - |
dc.subject | CELLS | - |
dc.subject | TRANSITIONS | - |
dc.subject | FIBROBLASTS | - |
dc.title | Intratumoral phenotypic heterogeneity as an encourager of cancer invasion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Seok | - |
dc.identifier.doi | 10.1039/c4ib00022f | - |
dc.identifier.scopusid | 2-s2.0-84903313525 | - |
dc.identifier.wosid | 000338298200001 | - |
dc.identifier.bibliographicCitation | INTEGRATIVE BIOLOGY, v.6, no.7, pp.654 - 661 | - |
dc.relation.isPartOf | INTEGRATIVE BIOLOGY | - |
dc.citation.title | INTEGRATIVE BIOLOGY | - |
dc.citation.volume | 6 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 654 | - |
dc.citation.endPage | 661 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | TUMOR HETEROGENEITY | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSITIONS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
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