Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic sclerosis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, G. G. | - |
dc.contributor.author | Lee, Y. H. | - |
dc.date.accessioned | 2021-09-05T17:17:32Z | - |
dc.date.available | 2021-09-05T17:17:32Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1676-5680 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101161 | - |
dc.description.abstract | The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was conducted in overall and European populations using 1) allelic contrast (D vs I); 2) recessive (DD vs ID + II); 3) dominant (DD + ID vs II); and 4) additive (DD vs ID vs II) models. A total of 7 studies consisting of 837 cases and 754 controls were available for meta-analysis. The meta-analysis revealed no association between the D allele and SSc in any study subjects [odds ratio (OR) = 0.956, 95% confidence interval (CI) = 0.733-1.246, P = 0.737]. Stratification by ethnicity indicated no association between the D allele of the ACE I/D polymorphism and SSc in Europeans (OR = 1.117, 95% CI = 0.776-1.607, P = 0.551). Meta-analysis using all other genetic models showed the same D allele pattern in the overall and European groups. This meta-analysis showed that the ACE I/D polymorphism was not associated with susceptibility to SSc in the study subjects and in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FUNPEC-EDITORA | - |
dc.subject | LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENE | - |
dc.subject | ACE | - |
dc.subject | DISEASE | - |
dc.subject | I/D | - |
dc.title | Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic sclerosis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, G. G. | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.4238/2014.October.7.12 | - |
dc.identifier.scopusid | 2-s2.0-84907855234 | - |
dc.identifier.wosid | 000345119800012 | - |
dc.identifier.bibliographicCitation | GENETICS AND MOLECULAR RESEARCH, v.13, no.4, pp.8174 - 8183 | - |
dc.relation.isPartOf | GENETICS AND MOLECULAR RESEARCH | - |
dc.citation.title | GENETICS AND MOLECULAR RESEARCH | - |
dc.citation.volume | 13 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 8174 | - |
dc.citation.endPage | 8183 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ACE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | I/D | - |
dc.subject.keywordAuthor | Angiotensin-converting enzyme | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Systemic sclerosis | - |
dc.subject.keywordAuthor | Association | - |
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