A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis
- Authors
- Song, Gwan Gyu; Lee, Young Ho
- Issue Date
- 2014
- Publisher
- INFORMA HEALTHCARE
- Keywords
- Endometriosis; meta-analysis; p53; polymorphism
- Citation
- IMMUNOLOGICAL INVESTIGATIONS, v.43, no.6, pp.595 - 605
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGICAL INVESTIGATIONS
- Volume
- 43
- Number
- 6
- Start Page
- 595
- End Page
- 605
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101199
- DOI
- 10.3109/08820139.2013.833623
- ISSN
- 0882-0139
- Abstract
- Objective: The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis. Methods: A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast. Results: Nine studies involving 1,803 patients and 2,006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921-1.282, p = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065-1.854, p = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123-3.730, p = 0.019). Conclusions: This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans.
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