Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug-gene co-delivery to cancer cells
DC Field | Value | Language |
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dc.contributor.author | Chen, Chih-Kuang | - |
dc.contributor.author | Law, Wing-Cheung | - |
dc.contributor.author | Aalinkeel, Ravikumar | - |
dc.contributor.author | Yu, Yun | - |
dc.contributor.author | Nair, Bindukumar | - |
dc.contributor.author | Wu, Jincheng | - |
dc.contributor.author | Mahajan, Supriya | - |
dc.contributor.author | Reynolds, Jessica L. | - |
dc.contributor.author | Li, Yukun | - |
dc.contributor.author | Lai, Cheng Kee | - |
dc.contributor.author | Tzanakakis, Emmanuel S. | - |
dc.contributor.author | Schwartz, Stanley A. | - |
dc.contributor.author | Prasad, Paras N. | - |
dc.contributor.author | Cheng, Chong | - |
dc.date.accessioned | 2021-09-05T17:24:18Z | - |
dc.date.available | 2021-09-05T17:24:18Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101209 | - |
dc.description.abstract | Having unique architectural features, cationic polymeric nanocapsules (NCs) with well-defined covalently stabilized biodegradable structures were generated as potentially universal and safe therapeutic nanocarriers. These NCs were synthesized from allyl-functionalized cationic polylactide (CPLA) by highly efficient UV-induced thiol-ene interfacial cross-linking in transparent miniemulsions. With tunable nanoscopic sizes, negligible cytotoxicity and remarkable degradability, they are able to encapsulate doxorubicin (Dox) with inner cavities and bind interleukin-8 (IL-8) small interfering RNA (siRNA) with cationic shells. The Dox-encapsulated NCs can effectively bypass the P-glycoprotein (Pgp)-mediated multidrug resistance of MCF7/ADR cancer cells, thereby resulting in increased intracellular drug concentration and reduced cell viability. In vitro studies also showed that the NCs loaded with Dox, IL-8 siRNA and both agents can be readily taken up by PC3 prostate cancer cells, resulting in a significant chemotherapeutic effect and/or IL-8 gene silencing. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | BLOCK-COPOLYMER MICELLES | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | NANOPARTICLES | - |
dc.subject | NANOSTRUCTURES | - |
dc.subject | NANOCARRIERS | - |
dc.subject | DOXORUBICIN | - |
dc.subject | CAPSULES | - |
dc.subject | THERAPY | - |
dc.subject | DESIGN | - |
dc.subject | CHEMOTHERAPY | - |
dc.title | Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug-gene co-delivery to cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Prasad, Paras N. | - |
dc.identifier.doi | 10.1039/c3nr04804g | - |
dc.identifier.scopusid | 2-s2.0-84892667514 | - |
dc.identifier.wosid | 000330041400045 | - |
dc.identifier.bibliographicCitation | NANOSCALE, v.6, no.3, pp.1567 - 1572 | - |
dc.relation.isPartOf | NANOSCALE | - |
dc.citation.title | NANOSCALE | - |
dc.citation.volume | 6 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1567 | - |
dc.citation.endPage | 1572 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | CAPSULES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
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