Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery
- Authors
- Koo, Heebeom; Min, Kyung Hyun; Lee, Sang Cheon; Park, Jae Hyung; Park, Kinam; Jeong, Seo Young; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwangmeyung
- Issue Date
- 28-12월-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Hydrotropic oligomer; Glycol chitosan nanoparticles; Tumor-targeting; Paclitaxel; Drug delivery; Cancer therapy
- Citation
- JOURNAL OF CONTROLLED RELEASE, v.172, no.3, pp.823 - 831
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CONTROLLED RELEASE
- Volume
- 172
- Number
- 3
- Start Page
- 823
- End Page
- 831
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101263
- DOI
- 10.1016/j.jconrel.2013.08.297
- ISSN
- 0168-3659
- Abstract
- Enhanced drug-loading and therapeutic efficacies are highly essential properties for nanoparticles as tumor-targeting drug carriers. Herein, we developed the glycol chitosan nanoparticles with hydrotropic oligomers (HO-CNPs) as a new tumor targeting drug delivery system. For enhancing drug-loading efficiency of paclitaxel in drug carriers, hydrotropic 2-(4-(vinylbenzyloxy)-N,N-diethylnicotinamide) (VBODENA-COOH) oligomers, that were used for enhancing the aqueous solubility of paclitaxel, were directly conjugated to glycol chitosan polymers. The amphiphilic conjugates readily formed nanoparticle structure (average size = 302 +/- 22 nm) in aqueous condition. Water-insoluble paclitaxel (PTX) was readily encapsulated into HO-CNPs with a high drug-loading amount up to 24.2 wt.% (2.4 fold higher than other polymeric nanoparticles) by a simple dialysis method. The PTX encapsulated HO-CNPs (PTX-HO-CNPs; average size = 343 +/- 12 nm) were very stable in aqueous media up to 50 days. Also, PTX-HO-CNPs presented rapid cellular uptake and lower cytotoxicity in cell culture system, compared to Cremophor EL/ethanol formulation of PTX. In tumor-bearing mice, the extravasation and accumulation of PTX-HO-CNPs in tumor tissue were precisely observed by intravital fluorescence imaging techniques. Furthermore, PTX-HO-CNPs showed the higher therapeutic efficacy, compared to Abraxane (R), a commercialized PTX-formulation. These overall results demonstrate its potential as a new nano-sized PTX carrier for cancer treatment. (C) 2013 Elsevier B.V. All rights reserved.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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