Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
DC Field | Value | Language |
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dc.contributor.author | Kang, Purum | - |
dc.contributor.author | Kim, Ka Young | - |
dc.contributor.author | Lee, Hui Su | - |
dc.contributor.author | Min, Sun Seek | - |
dc.contributor.author | Seol, Geun Hee | - |
dc.date.accessioned | 2021-09-05T18:00:32Z | - |
dc.date.available | 2021-09-05T18:00:32Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-12-05 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101313 | - |
dc.description.abstract | Aims: Anethole, the major component of the essential oil of star anise, has been reported to have antioxidant, antibacterial, antifungal, anti-inflammatory, and anesthetic properties. In this study, we investigated the anti-inflammatory effects of anethole in a mouse model of acute lung injury induced by lipopolysaccharide (LPS). Main methods: BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h. The anti-inflammatory effects of anethole were assessed by measuring total protein and cell levels and inflammatory mediator production and by histological evaluation and Western blot analysis. Key findings: LPS significantly increased total protein levels; numbers of total cells, including macrophages and neutrophils; and the production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and nitric oxide (NO) in bronchoalveolar lavage fluid. Anethole (250 mg/kg) decreased total protein concentrations; numbers of inflammatory cells, including neutrophils and macrophages; and the inflammatory mediators MMP-9, TNE-alpha and NO. In addition, pretreatment with anethole decreased LPS-induced histopathological changes. The anti-inflammatory mechanism of anethole in LPS-induced acute lung injury was assessed by investigating the effects of anethole on NF-kappa B activation. Anethole suppressed the activation of NF-kappa B by blocking I kappa B-alpha degradation. Significance: These results, showing that anethole prevents LPS-induced acute lung inflammation in mice, suggest that anethole may be therapeutically effective in inflammatory conditions in humans. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | INFLAMMATION | - |
dc.subject | INVOLVEMENT | - |
dc.subject | APOPTOSIS | - |
dc.title | Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seol, Geun Hee | - |
dc.identifier.doi | 10.1016/j.lfs.2013.10.014 | - |
dc.identifier.scopusid | 2-s2.0-84888294395 | - |
dc.identifier.wosid | 000328007300007 | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.93, no.24, pp.955 - 961 | - |
dc.relation.isPartOf | LIFE SCIENCES | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 93 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 955 | - |
dc.citation.endPage | 961 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | Anethole | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | Acute lung injury | - |
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