Phase 2 Trial of Accelerated, Hypofractionated Whole-Breast Irradiation of 39 Gy in 13 Fractions Followed by a Tumor Bed Boost Sequentially Delivering 9 Gy in 3 Fractions in Early-Stage Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Ja Young | - |
dc.contributor.author | Jung, So-Youn | - |
dc.contributor.author | Lee, Seeyoun | - |
dc.contributor.author | Kang, Han-Sung | - |
dc.contributor.author | Lee, Eun Sook | - |
dc.contributor.author | Park, In Hae | - |
dc.contributor.author | Lee, Keun Seok | - |
dc.contributor.author | Ro, Jungsil | - |
dc.contributor.author | Lee, Nam Kwon | - |
dc.contributor.author | Shin, Kyung Hwan | - |
dc.date.accessioned | 2021-09-05T18:08:07Z | - |
dc.date.available | 2021-09-05T18:08:07Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-12-01 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101339 | - |
dc.description.abstract | Purpose: To report a phase 2 trial of accelerated, hypofractionated whole-breast irradiation (AH-WBI) delivered as a daily dose of 3 Gy to the whole breast followed by a tumor bed boost. Methods and Materials: Two hundred seventy-six patients diagnosed with breast cancer (pT1-2 and pN0-1a) who had undergone breast-conserving surgery in which the operative margins were negative were treated with AH-WBI delivered as 39 Gy in 13 fractions of 3 Gy to the whole breast once daily over 5 consecutive working days, and 9 Gy in 3 sequential fractions of 3 Gy to a lumpectomy cavity, all within 3.2 weeks. Results: After a median follow-up period of 57 months (range: 27-75 months), the rate of 5-year locoregional recurrence was 1.4%(n=4), whereas that of disease-free survival was 97.4%. No grade 3 skin toxicity was reported during the follow-up period. Qualitative physician cosmetic assessments of good or excellent were noted in 82% of the patients at 2 months after the completion of AH-WBI. The global cosmetic outcome did not worsen over time, and a good or excellent cosmetic outcome was reported in 82% of the patients at 3 years. The mean pretreatment percentage breast retraction assessment was 12.00 (95% confidence interval [CI]: 11.14-12.86). The mean value of percentage breast retraction assessment increased to 13.99 (95% CI: 12.17-15.96) after 1 year and decreased to 13.54 (95% CI: 11.84-15.46) after 3 years but was not significant (P>.05). Conclusions: AH-WBI consisting of 39 Gy in 13 fractions followed by a tumor bed boost sequentially delivering 9 Gy in 3 fractions can be delivered with excellent disease control and tolerable skin toxicity in patients with early-stage breast cancer after breast-conserving surgery. (C) 2013 Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | CONSERVING THERAPY | - |
dc.subject | RADIATION-THERAPY | - |
dc.subject | RADIOTHERAPY HYPOFRACTIONATION | - |
dc.subject | UK STANDARDIZATION | - |
dc.subject | EORTC BOOST | - |
dc.title | Phase 2 Trial of Accelerated, Hypofractionated Whole-Breast Irradiation of 39 Gy in 13 Fractions Followed by a Tumor Bed Boost Sequentially Delivering 9 Gy in 3 Fractions in Early-Stage Breast Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Nam Kwon | - |
dc.identifier.doi | 10.1016/j.ijrobp.2013.09.019 | - |
dc.identifier.wosid | 000327496600036 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, v.87, no.5, pp.1037 - 1042 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.citation.volume | 87 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1037 | - |
dc.citation.endPage | 1042 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | CONSERVING THERAPY | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | RADIOTHERAPY HYPOFRACTIONATION | - |
dc.subject.keywordPlus | UK STANDARDIZATION | - |
dc.subject.keywordPlus | EORTC BOOST | - |
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