A Phase-Field Model for Articular Cartilage Regeneration in Degradable Scaffolds
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Ana | - |
dc.contributor.author | Lee, Soon-Hyuck | - |
dc.contributor.author | Kim, Junseok | - |
dc.date.accessioned | 2021-09-05T18:10:06Z | - |
dc.date.available | 2021-09-05T18:10:06Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0092-8240 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101352 | - |
dc.description.abstract | Degradable scaffolds represent a promising solution for tissue engineering of damaged or degenerated articular cartilage which due to its avascular nature, is characterized by a low self-repair capacity. To estimate the articular cartilage regeneration process employing degradable scaffolds, we propose a mathematical model as the extension of Olson and Haider's work (Int. J. Pure Appl. Math. 53:333-353, 2009). The simulated tissue engineering procedure consists in (i) the explant of a cylindrical sample, (ii) the removal of the inner core region, and (iii) the filling of the inner region with hydrogels, degradable scaffolds enriched with nutrients, such as oxygen and glucose. The phase-field model simulates the cartilage regeneration process at the scaffold-cartilage interface. It embeds reaction-diffusion equations, which are used to model the nutrient and regenerated extracellular matrix. The equations are solved using an unconditionally stable hybrid numerical scheme. Cartilage repair processes with full-thickness defects, which are controlled by properties of hydrogel materials and cartilage explant culture based on biological interest are observed. The implemented mathematical model shows the capability to simulate cartilage repairing processes, which can be virtually controlled evaluating hydrogel and cartilage material properties including nutrient supply and defected magnitude. In particular, the adopted methodology is able to explain the regeneration time of cartilage within hydrogel environments. With the numerical scheme, the numerical simulations are demonstrated for the potential improvement of hydrogel structures. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | NUMERICAL-METHOD | - |
dc.subject | CONTINUUM MODEL | - |
dc.subject | TISSUE | - |
dc.subject | HYDROGELS | - |
dc.subject | PROLIFERATION | - |
dc.subject | DIFFUSION | - |
dc.subject | EQUATION | - |
dc.subject | DEFECTS | - |
dc.subject | GROWTH | - |
dc.title | A Phase-Field Model for Articular Cartilage Regeneration in Degradable Scaffolds | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Soon-Hyuck | - |
dc.contributor.affiliatedAuthor | Kim, Junseok | - |
dc.identifier.doi | 10.1007/s11538-013-9897-3 | - |
dc.identifier.scopusid | 2-s2.0-84887579002 | - |
dc.identifier.wosid | 000327073000005 | - |
dc.identifier.bibliographicCitation | BULLETIN OF MATHEMATICAL BIOLOGY, v.75, no.12, pp.2389 - 2409 | - |
dc.relation.isPartOf | BULLETIN OF MATHEMATICAL BIOLOGY | - |
dc.citation.title | BULLETIN OF MATHEMATICAL BIOLOGY | - |
dc.citation.volume | 75 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2389 | - |
dc.citation.endPage | 2409 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Mathematical & Computational Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Mathematical & Computational Biology | - |
dc.subject.keywordPlus | NUMERICAL-METHOD | - |
dc.subject.keywordPlus | CONTINUUM MODEL | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | EQUATION | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Phase-field model | - |
dc.subject.keywordAuthor | Articular cartilage regeneration | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordAuthor | Reaction-diffusion model | - |
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