The effects of functionalized titanium with alendronate and bone morphogenic protein-2 for improving osteoblast activity
- Authors
- Kim, Sung Eun; Yun, Young-Pil; Park, Kyeongsoon; Kim, Hak-Jun; Lee, Deok-Won; Kim, Jung Wook; Yang, Dae Hyeok; Suh, Dong Hun
- Issue Date
- 12월-2013
- Publisher
- KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
- Keywords
- alendronate; bone morphogenic protein-2 (BMP-2); functionalized titanium (Ti); osteoblast activity
- Citation
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.10, no.6, pp.353 - 361
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- Volume
- 10
- Number
- 6
- Start Page
- 353
- End Page
- 361
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101388
- DOI
- 10.1007/s13770-013-1098-5
- ISSN
- 1738-2696
- Abstract
- The aim of this study was to investigate the effect of functionalized titanium (Ti) with alendronate (Aln) and bone morphogenic protein-2 (BMP-2) for enhancement of osteoblast activity in vitro. Aln and/or BMP-2 were sequentially immobilized to the heparinized-Ti (Hep-Ti) surface. The compositions of pristine Ti and Hep-Ti with or without Aln and/or BMP-2 were characterized by scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). Aln and/or BMP-2 onto Hep-Ti surface were released in a sustained manner. Osteoblast activities on all Ti substrates were investigated by cell proliferation assays, alkaline phosphate (ALP) activity, calcium deposition, gene expressions of osteocalcin and osteopontin. Aln/BMP-2/Hep-Ti significantly enhanced ALP activity, calcium mineral deposition, and gene expressions of osteoblast cells when compared with pristine Ti, Aln/Hep-Ti, and BMP-2/Hep-Ti. From these results, functionalized Ti substrates with alendronate and BMP-2 such as Aln/BMP-2/Hep-Ti are a promising material for the enhanced osteoblast activities in orthopedic and dental fields.
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