Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Hong, Ho Cheol | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Lee, Kwan Woo | - |
dc.contributor.author | Nam, Moon Suk | - |
dc.contributor.author | Park, Yong Soo | - |
dc.contributor.author | Woo, Jeong Taek | - |
dc.contributor.author | Kim, Young Seol | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.date.accessioned | 2021-09-05T18:16:53Z | - |
dc.date.available | 2021-09-05T18:16:53Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1355-008x | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101400 | - |
dc.description.abstract | Omentin-1 is an adipokine implicated in diabetes, inflammation, and cardiovascular disease. However, no prospective studies have examined the impact of circulating omentin-1 levels on arterial stiffening in patients with type 2 diabetes mellitus. For the purpose of this study, we recruited 120 patients with type 2 diabetes mellitus and measured serum omentin-1, adiponectin, and high-sensitivity C-reactive protein levels as well as other cardiovascular risk factors. Arterial stiffness was assessed by brachial ankle pulse wave velocity (baPWV). An increase in the level of circulating omentin-1 over a period of 1 year was positively correlated with changes in levels of HbA1c and serum adiponectin as well as baPWV. Subjects with higher baseline serum omentin-1 levels tended to have a reduced arterial stiffness after 1 year (P for linear trend = 0.03). In the group with increased baPWV after 1 year, the magnitude of increase of circulating omentin-1 levels was significantly higher than in the group with a lower baPWV after 1 year (134.3 [16.6, 277.1] ng/mL vs. 15.9 [-67.6, 145.7] ng/mL, P < 0.01). Multiple stepwise logistic regression analysis revealed that an increase in systolic blood pressure and an increase in serum omentin-1 level were independently correlated with arterial stiffening, even after adjusting for other cardiovascular risk factors and medication history. Baseline serum omentin-1 levels can predict arterial stiffness changes occurring within a year. Furthermore, changes in serum omentin-1 levels after a year can function as independent markers of arterial stiffening in patients with type 2 diabetes mellitus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | STIFFNESS | - |
dc.subject | DISEASE | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ADIPOCYTOKINE | - |
dc.subject | EXPRESSION | - |
dc.subject | ADIPOKINE | - |
dc.subject | INSULIN | - |
dc.subject | CLONING | - |
dc.subject | WOMEN | - |
dc.title | Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.identifier.doi | 10.1007/s12020-013-9930-1 | - |
dc.identifier.scopusid | 2-s2.0-84890805602 | - |
dc.identifier.wosid | 000327396300017 | - |
dc.identifier.bibliographicCitation | ENDOCRINE, v.44, no.3, pp.680 - 687 | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.citation.title | ENDOCRINE | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 680 | - |
dc.citation.endPage | 687 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ADIPOCYTOKINE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ADIPOKINE | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | Omentin-1 | - |
dc.subject.keywordAuthor | Vascular stiffness | - |
dc.subject.keywordAuthor | Adipokines | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
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