SIRT1 suppresses cellular accumulation of beta-TrCP E3 ligase via protein degradation
DC Field | Value | Language |
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dc.contributor.author | Woo, Seon Rang | - |
dc.contributor.author | Byun, Jae Gwang | - |
dc.contributor.author | Kim, Yang Hyun | - |
dc.contributor.author | Park, Eun-Ran | - |
dc.contributor.author | Joo, Hyun-Yoo | - |
dc.contributor.author | Yun, Miyong | - |
dc.contributor.author | Shin, Hyun-Jin | - |
dc.contributor.author | Kim, Su-Hyeon | - |
dc.contributor.author | Shen, Yan Nan | - |
dc.contributor.author | Park, Jeong-Eun | - |
dc.contributor.author | Park, Gil-Hong | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.date.accessioned | 2021-09-05T18:51:15Z | - |
dc.date.available | 2021-09-05T18:51:15Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-11-29 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101553 | - |
dc.description.abstract | beta-Transducin repeat-containing protein (beta-TrCP), an E3 ligase, promotes the degradation of substrate proteins in response to various stimuli. Even though several beta-TrCP substrates have been identified to date, limited information of its upstream regulators is available. Here, we showed that SIRT1 suppresses beta-TrCP protein synthesis via post-translational degradation. SIRT1 depletion led to a significant increase in the beta-TrCP accumulation without affecting the mRNA level. Consistently, beta-TrCP protein accumulation induced by resveratrol was further enhanced upon SIRT1 depletion. Rescue of SIRT1 reversed the effect of resveratrol, leading to reduced beta-TrCP protein levels. Proteasomal inhibition led to recovery of beta-TrCP in cells with SIRT1 overexpression. Notably, the recovered beta-TrCP colocalized mostly with SIRT1. Thus, SIRT1 acts as a negative regulator of beta-TrCP synthesis via promoting protein degradation. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | UBIQUITIN LIGASE | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | RESVERATROL | - |
dc.subject | INHIBITION | - |
dc.subject | CELLS | - |
dc.subject | THIAZOLIDINEDIONES | - |
dc.subject | RECEPTOR | - |
dc.subject | PATHWAY | - |
dc.subject | APOPTOSIS | - |
dc.subject | MODULATE | - |
dc.title | SIRT1 suppresses cellular accumulation of beta-TrCP E3 ligase via protein degradation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Gil-Hong | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.10.146 | - |
dc.identifier.scopusid | 2-s2.0-84888855962 | - |
dc.identifier.wosid | 000328434800024 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.441, no.4, pp.831 - 837 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 441 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 831 | - |
dc.citation.endPage | 837 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | THIAZOLIDINEDIONES | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MODULATE | - |
dc.subject.keywordAuthor | beta-TrCP | - |
dc.subject.keywordAuthor | SIRT1 | - |
dc.subject.keywordAuthor | Post-translational degradation | - |
dc.subject.keywordAuthor | Pyruvate | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | Nucleus | - |
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