Relationships of Coagulation Factor XIII Activity with Cell-Type and Stage of Non-Small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Heon | - |
dc.contributor.author | Suh, In Bum | - |
dc.contributor.author | Lee, Eun Joo | - |
dc.contributor.author | Nur, Gyu Young | - |
dc.contributor.author | Lee, Sung Yong | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Shim, Jae Jeong | - |
dc.contributor.author | In, Kwang Ho | - |
dc.contributor.author | Kang, Kyung Ho | - |
dc.contributor.author | Yoo, Se Hwa | - |
dc.contributor.author | Kim, Je Hyeong | - |
dc.date.accessioned | 2021-09-05T19:25:12Z | - |
dc.date.available | 2021-09-05T19:25:12Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-11-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101649 | - |
dc.description.abstract | Purpose: Factor XIII (FXIII), a thrombin-activated plasma transglutaminase zymogen, is involved in cancer development and progression through a triggered coagulation pathway. The aim of this study was to examine whether FM activity levels differed in non-small cell lung cancer (NSCLC) patients according to histological types and TNM stage when compared with healthy subjects. Materials and Methods: Twenty-eight NSCLC patients and 28 normal controls who had been individually age-, gender-, body mass index-, smoking status-, and smoking amount-matched were enrolled: 13 adenocarcinomas, 11 squamous cell carcinomas, and four undifferentiated NSCLCs; four stage I, two stage II, 12 stage III, and 10 stage IV NSCLCs. FXIII activity was measured using fluorescence-based protein arrays. Results: The median FXIII activity level of the NSCLC group [24.2 Loewy U/mL, interquartile range (IQR) 14.9-40.4 Loewy U/mL] was significantly higher than that of the healthy group (17.5 Loewy U/mL, IQR 12.6-26.4 Loewy U/mL) (p=0.01). There were no differences in FXIII activity between adenocarcinoma (median 18.6 Loewy U/mL) and squamous cell carcinoma (median 28.7 Loewy U/mL). NSCLC stage significantly influenced FXIII activity (p=0.02). The FXIII activity of patients with stage HI NSCLC (median 27.3 Loewy U/mL IQR 19.3-40.5 Loewy U/mL) was significantly higher than those of patients with stage I or II (median 14.0 Loewy U/mL, IQR 13.1-23.1 Loewy U/mL, p=0.04). FXIII activity was negatively correlated with aPTT in NSCLC patients (r=-0.38, p=0.04). Conclusion: Patients with advanced-stage NSCLC exhibited higher coagulation FXIII activity than healthy controls and early-stage NSCLC patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | SUBUNIT-A | - |
dc.subject | FIBRINOGEN | - |
dc.subject | METASTASIS | - |
dc.subject | TRANSGLUTAMINASE | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | PREVALENCE | - |
dc.subject | EXPRESSION | - |
dc.subject | MALIGNANCY | - |
dc.subject | MARKERS | - |
dc.subject | GROWTH | - |
dc.title | Relationships of Coagulation Factor XIII Activity with Cell-Type and Stage of Non-Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Seung Heon | - |
dc.contributor.affiliatedAuthor | Lee, Eun Joo | - |
dc.contributor.affiliatedAuthor | Nur, Gyu Young | - |
dc.contributor.affiliatedAuthor | Lee, Sung Yong | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeub | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.contributor.affiliatedAuthor | Shim, Jae Jeong | - |
dc.contributor.affiliatedAuthor | In, Kwang Ho | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Ho | - |
dc.contributor.affiliatedAuthor | Kim, Je Hyeong | - |
dc.identifier.doi | 10.3349/ymj.2013.54.6.1394 | - |
dc.identifier.scopusid | 2-s2.0-84886529771 | - |
dc.identifier.wosid | 000326415500013 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.54, no.6, pp.1394 - 1399 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 54 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1394 | - |
dc.citation.endPage | 1399 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001813916 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SUBUNIT-A | - |
dc.subject.keywordPlus | FIBRINOGEN | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MALIGNANCY | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Factor XIII | - |
dc.subject.keywordAuthor | histological type | - |
dc.subject.keywordAuthor | neoplasm staging | - |
dc.subject.keywordAuthor | non-small-cell lung carcinoma | - |
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