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Association of Total Marine Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acids, With Aortic Stiffness in Koreans, Whites, and Japanese Americans

Authors
Sekikawa, AkiraShin, CholMasaki, Kamal H.Barinas-Mitchell, Emma J. M.Hirooka, NobutakaWillcox, Bradley J.Choo, JinaWhite, JessicaEvans, Rhobert W.Fujiyoshi, AkiraOkamura, TomonoriMiura, KatsuyukiMuldoon, Matthew F.Ueshima, HirotsuguKuller, Lewis H.Sutton-Tyrrell, Kim
Issue Date
11월-2013
Publisher
OXFORD UNIV PRESS
Keywords
aortic stiffness; blood pressure; carotid femoral pulse wave velocity; docosahexaenoic acid; eicosapentaenoic acid; fish oil; hypertension
Citation
AMERICAN JOURNAL OF HYPERTENSION, v.26, no.11, pp.1321 - 1327
Indexed
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF HYPERTENSION
Volume
26
Number
11
Start Page
1321
End Page
1327
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101737
DOI
10.1093/ajh/hpt107
ISSN
0895-7061
Abstract
Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotidfemoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men. A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 20022006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders. Mean EPA and DHA levels were 1.9 (SD 1.0) and 4.8 (SD 1.4) for Koreans, 0.8 (SD 0.6) and 2.4 (SD 1.2) for whites, and 1.0 (SD 1.0) and 3.2 (SD 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P < 0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA. High levels of EPA observed in Koreans have an inverse association with aortic stiffness.
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