Effects of Polymorphisms of the SLCO2B1 Transporter Gene on the Pharmacokinetics of Montelukast in Humans
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung-Ah | - |
dc.contributor.author | Lee, Hye-Mi | - |
dc.contributor.author | Joo, Hyun-Jin | - |
dc.contributor.author | Park, In-Bae | - |
dc.contributor.author | Park, Ji-Young | - |
dc.date.accessioned | 2021-09-05T19:49:00Z | - |
dc.date.available | 2021-09-05T19:49:00Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0091-2700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101793 | - |
dc.description.abstract | Montelukast, a leukotriene receptor antagonist, is a substrate of organic anion transporting OATP2B1 encoded by the SLCO2B1. We evaluated the effects of six non-synonymous (c.1175C>T, c.1457C>T, c.43C>T, c.935G>A, c.601G>A, and c.644A>T) polymorphisms and one promoter (g.-282G>A) polymorphism on the pharmacokinetics of montelukast. A single dose of 10mg montelukast was administered in 24 healthy subjects. Its levels were measured up to 24hours and a pharmacokinetic analysis was performed based on the SLCO2B1 polymorphisms. We did not encounter subjects with c.1175C>T, c.43C>T, or c.644A>T polymorphisms. The remaining SLCO2B1 polymorphisms did not affect plasma levels of montelukast, and pharmacokinetic parameters of montelukast did not differ among genotype groups. Oral clearance results were as follows: (1) 3.3L/h for c.935GG, 3.0L/h for c.935GA, and 3.5L/h for c.935AA; (2) 3.4L/h for c.1457CC, 2.9L/h for c.1457CT, and 3.2L/h for c.1457TT; (3) 3.2L/h for c.601GG, 3.4L/h for c.601GA, and 3.4L/h for c.601AA; (4) 3.2L/h for g.-282GG, 3.4L/h for g.-282GA, and 3.2L/h for g.-282AA. The findings suggest that SLCO2B1 polymorphisms do not affect the pharmacokinetics of montelukast and that SLCO2B1 polymorphisms appear to be a minor determinant of inter-individual variability of montelukast. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | LEUKOTRIENE RECEPTOR ANTAGONISTS | - |
dc.subject | REDUCED PLASMA-CONCENTRATIONS | - |
dc.subject | COMMON VARIANT | - |
dc.subject | APPLE JUICE | - |
dc.subject | ABSORPTION | - |
dc.subject | OATP2B1 | - |
dc.subject | ASTHMA | - |
dc.subject | PHARMACOLOGY | - |
dc.subject | FEXOFENADINE | - |
dc.subject | POPULATION | - |
dc.title | Effects of Polymorphisms of the SLCO2B1 Transporter Gene on the Pharmacokinetics of Montelukast in Humans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.1002/jcph.144 | - |
dc.identifier.scopusid | 2-s2.0-84892919369 | - |
dc.identifier.wosid | 000325865700010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PHARMACOLOGY, v.53, no.11, pp.1186 - 1193 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PHARMACOLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL PHARMACOLOGY | - |
dc.citation.volume | 53 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1186 | - |
dc.citation.endPage | 1193 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | LEUKOTRIENE RECEPTOR ANTAGONISTS | - |
dc.subject.keywordPlus | REDUCED PLASMA-CONCENTRATIONS | - |
dc.subject.keywordPlus | COMMON VARIANT | - |
dc.subject.keywordPlus | APPLE JUICE | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | OATP2B1 | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | PHARMACOLOGY | - |
dc.subject.keywordPlus | FEXOFENADINE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | montelukast | - |
dc.subject.keywordAuthor | SLCO2B1 | - |
dc.subject.keywordAuthor | OATP2B1 | - |
dc.subject.keywordAuthor | pharmacogenetics | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
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