Interleukin-6 but not tumour necrosis factor-alpha predicts survival in patients with advanced cancer
DC Field | Value | Language |
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dc.contributor.author | Suh, Sang-Yeon | - |
dc.contributor.author | Choi, Youn Seon | - |
dc.contributor.author | Yeom, Chang Hwan | - |
dc.contributor.author | Kwak, Sang Mi | - |
dc.contributor.author | Yoon, Ho Min | - |
dc.contributor.author | Kim, Dae Gyun | - |
dc.contributor.author | Koh, Su-Jin | - |
dc.contributor.author | Park, Jeanno | - |
dc.contributor.author | Lee, Myung Ah | - |
dc.contributor.author | Lee, Yong Joo | - |
dc.contributor.author | Seo, Ah-Ram | - |
dc.contributor.author | Ahn, Hong-Yup | - |
dc.contributor.author | Yim, Eunji | - |
dc.date.accessioned | 2021-09-05T19:52:43Z | - |
dc.date.available | 2021-09-05T19:52:43Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0941-4355 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101815 | - |
dc.description.abstract | The purpose of this study was to evaluate the prognostic role of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in the survival of patients with advanced cancer. In this prospective cohort study between three hospice and palliative care centres in South Korea, we followed 98 advanced cancer patients until death or the end of the study. Approximately 60 % of the patients had poor functional status (Eastern Cooperative Oncology Group score a parts per thousand yen3). We investigated the symptoms of cancer cachexia anorexia syndrome, possible cytokine-related confounders such as infection and medication records. Influence from clinical variables was adjusted using the Cox proportional hazard model. The median survival time was 27 days. On multivariate analysis, elevated IL-6 (hazard ratio, 2.139; p = 0.003) was found to be an independent significant prognostic factor. TNF-alpha was not a significant factor. Poor performance status and male gender were also independently related to shortened survival. IL-6 level can be a useful indicator of survival time of patients with advanced cancer at the very end of life. In contrast, the prognostic role of TNF-alpha requires further study. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | MURINE MONOCLONAL-ANTIBODY | - |
dc.subject | ADVANCED MULTIPLE-MYELOMA | - |
dc.subject | BRIEF FATIGUE INVENTORY | - |
dc.subject | ACUTE-PHASE RESPONSE | - |
dc.subject | PROGNOSTIC-FACTORS | - |
dc.subject | PALLIATIVE-CARE | - |
dc.subject | LUNG-CANCER | - |
dc.subject | WEIGHT-LOSS | - |
dc.subject | CYTOKINE | - |
dc.subject | TIME | - |
dc.title | Interleukin-6 but not tumour necrosis factor-alpha predicts survival in patients with advanced cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Youn Seon | - |
dc.identifier.doi | 10.1007/s00520-013-1878-4 | - |
dc.identifier.scopusid | 2-s2.0-84885572117 | - |
dc.identifier.wosid | 000325390600016 | - |
dc.identifier.bibliographicCitation | SUPPORTIVE CARE IN CANCER, v.21, no.11, pp.3071 - 3077 | - |
dc.relation.isPartOf | SUPPORTIVE CARE IN CANCER | - |
dc.citation.title | SUPPORTIVE CARE IN CANCER | - |
dc.citation.volume | 21 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3071 | - |
dc.citation.endPage | 3077 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalResearchArea | Rehabilitation | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Rehabilitation | - |
dc.subject.keywordPlus | MURINE MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | ADVANCED MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | BRIEF FATIGUE INVENTORY | - |
dc.subject.keywordPlus | ACUTE-PHASE RESPONSE | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | PALLIATIVE-CARE | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordAuthor | Interleukin-6 | - |
dc.subject.keywordAuthor | Tumour necrosis factor-alpha | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordAuthor | Advanced cancer | - |
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