The effect of titanium with heparin/BMP-2 complex for improving osteoblast activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Su-Young | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.contributor.author | Chun, Heung Jae | - |
dc.contributor.author | Yang, Dae Hyeok | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.date.accessioned | 2021-09-05T20:11:38Z | - |
dc.date.available | 2021-09-05T20:11:38Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-10-15 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101862 | - |
dc.description.abstract | The objective of this study was to investigate the enhanced osteoblast activity of MG-63 cells cultured on titanium (Ti) with a heparin/BMP-2 (Hep/BMP-2) complex. The Ti substrates were initially modified by chemical grafting poly-L-lysine (PLL) using condensing agent, followed by immobilizing the heparin/BMP-2 complex to the PLL-grafted Ti substrate via electrostatic interactions. The surface modification of Ti substrates with PLL and/or Hep/BMP-2 complex were confirmed with scanning electron microscopy, contact angle measurements, and X-ray photoelectron spectroscopy. Immobilized BMP-2 was released from the Hep/BMP-2/Ti substrate in a sustained manner. In vitro studies revealed that osteoblasts grown on Hep/BMP-2/Ti substrate increased ALP activity, calcium deposition, ALP and osteocalcin levels as compared to those grown on pristine Ti or PLL-Ti. These results indicated that heparin/BMP-2 complex immobilized Ti substrate can be useful to effectively improve osteoblast activity. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | IN-VITRO | - |
dc.subject | OSTEOGENIC DIFFERENTIATION | - |
dc.subject | CONTROLLED-RELEASE | - |
dc.subject | CONJUGATED FIBRIN | - |
dc.subject | COLLAGEN MATRICES | - |
dc.subject | ENHANCEMENT | - |
dc.subject | SURFACES | - |
dc.subject | ADHESION | - |
dc.title | The effect of titanium with heparin/BMP-2 complex for improving osteoblast activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.identifier.doi | 10.1016/j.carbpol.2013.05.095 | - |
dc.identifier.scopusid | 2-s2.0-84885111763 | - |
dc.identifier.wosid | 000325835600071 | - |
dc.identifier.bibliographicCitation | CARBOHYDRATE POLYMERS, v.98, no.1, pp.546 - 554 | - |
dc.relation.isPartOf | CARBOHYDRATE POLYMERS | - |
dc.citation.title | CARBOHYDRATE POLYMERS | - |
dc.citation.volume | 98 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 546 | - |
dc.citation.endPage | 554 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | CONJUGATED FIBRIN | - |
dc.subject.keywordPlus | COLLAGEN MATRICES | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordAuthor | Titanium | - |
dc.subject.keywordAuthor | Osteoblast activity | - |
dc.subject.keywordAuthor | Bone morphogenic protein-2 (BMP-2) | - |
dc.subject.keywordAuthor | Heparin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.