A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yong-Geun | - |
dc.contributor.author | Ha, Chul-Won | - |
dc.contributor.author | Han, Chang-Dong | - |
dc.contributor.author | Bin, Seong-Il | - |
dc.contributor.author | Kim, Hee-Chun | - |
dc.contributor.author | Jung, Young-Bok | - |
dc.contributor.author | Lim, Hong-Chul | - |
dc.date.accessioned | 2021-09-05T20:19:23Z | - |
dc.date.available | 2021-09-05T20:19:23Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-10-07 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101892 | - |
dc.description.abstract | Ethnopharmacological relevance: This prospective, randomized, double-blind, multicenter study compared the efficacy and safety of Celecoxib and GCSB-5, a new product from extracts of six herbs, for the treatment of knee osteoarthritis. Materials and methods: A total of 198 eligible patients were randomly assigned to the Celecoxib group (n=99 patients) or the GCSB-5 group (n=99 patients) for the 12-week study. The amount of change and percentage of the change in Western Ontario and McMaster Universities (WOMAC) Arthritis Index from the baseline, the change in pain on walking by visual analogue scale (VAS), physician's global assessment on response to therapy (PGART) by five point Likert scale, and the amount of rescue medicine taken were used as parameters for efficacy. Adverse drug reactions (ADRs) were carefully investigated. Results: The WOMAC score improved in both the Celecoxib group and GCSB-5 group by 20.5 and 213 (P=0.79). The percentage of the change in WOMAC score were -42.0% and -38.9% (P=0.54). The pain VAS score decreased by 29.9 and 27.9 (P=0.58). The responders by PGART were 95.3% and 93.8% (P=0.66), and the median amount of rescue medicine taken were 2.0 and 6.5 tablets (P=0.06). The incidence of ADRs were 31.3% and 21.2% (P=0.11). The most common ADRs were gastrointestinal system related; 17.2% in GCSB-5 group and 22.2% in Celecoxib group. Any severe ADR was not observed in either group. Conclusions: The result of this study supports that GCSB-5 is comparable to Celecoxib in terms of the efficacy and safety for the treatment of osteoarthritis of knee joint. (C) 2013 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | PLACEBO | - |
dc.subject | TOLERABILITY | - |
dc.subject | INFLAMMATION | - |
dc.subject | COMBINATION | - |
dc.subject | INHIBITOR | - |
dc.subject | MECHANISM | - |
dc.title | A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Hong-Chul | - |
dc.identifier.doi | 10.1016/j.jep.2013.08.008 | - |
dc.identifier.scopusid | 2-s2.0-84884416455 | - |
dc.identifier.wosid | 000326215100026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.149, no.3, pp.816 - 824 | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 149 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 816 | - |
dc.citation.endPage | 824 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordPlus | TOLERABILITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | GCSB-5 | - |
dc.subject.keywordAuthor | Celecoxib | - |
dc.subject.keywordAuthor | Efficacy | - |
dc.subject.keywordAuthor | Knee | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.