Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Chung | - |
dc.contributor.author | Song, Sumi | - |
dc.contributor.author | Hwang, Sunyoung | - |
dc.contributor.author | Kim, Chorong | - |
dc.contributor.author | Kim, Minkyoung | - |
dc.contributor.author | Gu, Jail | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Lee, Kyeong | - |
dc.contributor.author | Kwon, Jinsun | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.contributor.author | Choi, Yongseok | - |
dc.date.accessioned | 2021-09-05T20:24:31Z | - |
dc.date.available | 2021-09-05T20:24:31Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-10-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101923 | - |
dc.description.abstract | A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | ROSMARINUS-OFFICINALIS | - |
dc.subject | BRAIN | - |
dc.subject | MECHANISMS | - |
dc.subject | NEURONS | - |
dc.subject | STROKE | - |
dc.title | Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.contributor.affiliatedAuthor | Kim, Won-Ki | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.identifier.doi | 10.1016/j.bmcl.2013.07.038 | - |
dc.identifier.scopusid | 2-s2.0-84883487187 | - |
dc.identifier.wosid | 000324302800032 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.19, pp.5421 - 5425 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 5421 | - |
dc.citation.endPage | 5425 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ROSMARINUS-OFFICINALIS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordAuthor | Cerebral ischemia | - |
dc.subject.keywordAuthor | Anti-oxidant activity | - |
dc.subject.keywordAuthor | Anti-excitotoxic activity | - |
dc.subject.keywordAuthor | Anti-ischemic activity | - |
dc.subject.keywordAuthor | Verbenone | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.