Current status of PET-imaging probes of beta-amyloid plaques
- Authors
- Koo, JaeHyung; Byun, Youngjoo
- Issue Date
- 10월-2013
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Amyloid plaques; PET-imaging; Alzheimer' s disease
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.36, no.10, pp.1178 - 1184
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 36
- Number
- 10
- Start Page
- 1178
- End Page
- 1184
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101953
- DOI
- 10.1007/s12272-013-0193-4
- ISSN
- 0253-6269
- Abstract
- Alzheimer's disease (AD) is the most common form of dementia and is characterized by progressive cognitive decline and memory loss. One of pathological hallmarks of AD is the accumulation and deposition of beta-amyloid (A beta) plaques which is a potential target for the early diagnosis of AD. Positron emission tomography (PET), a sensitive radionuclide imaging technique, has provided opportunities to detect A beta plaques of AD. PET-imaging probes of A beta plaques have been extensively developed during the last decade. [F-18]Florbetapir, the F-18-labeled PET-imaging probe of A beta plaques, was recently approved by US Food and Drug Administration. A number of follow-on PET-imaging probes are currently being developed in academia and pharmaceutical companies. This article will discuss the recent development of PET-imaging probes from [C-11]PIB to [F-18]Florbetapir, which are in clinic trials, and several follow-on probes in preclinical stage.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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