Hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation in adult patients with idiopathic aplastic anemia
DC Field | Value | Language |
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dc.contributor.author | Kim, Hawk | - |
dc.contributor.author | Lee, Kyoo-Hyung | - |
dc.contributor.author | Sohn, Sang Kyun | - |
dc.contributor.author | Jung, Chul Won | - |
dc.contributor.author | Joo, Young Don | - |
dc.contributor.author | Kim, Sung Hyun | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Choi, Jung Hye | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Bae, Sung Hwa | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.contributor.author | Won, Jong Ho | - |
dc.contributor.author | Oh, Sukjoong | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Park, Jae-Hoo | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.date.accessioned | 2021-09-05T20:45:38Z | - |
dc.date.available | 2021-09-05T20:45:38Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0145-2126 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102037 | - |
dc.description.abstract | We retrospectively investigated the incidence, risk factors, and outcomes of SOS (sinusoidal obstruction syndrome; previously veno-occlusive disease [VOD]) after allogeneic hematopoietic stem cell transplantation (alloHSCT) in aplastic anemia. Two hundred and sixty patients were included in the analysis. SOS developed in 7.3% (n = 19/260) of patients. Classical Cy (200 mg/m(2))-ATG was the most common conditioning regimen (84.2%) in the SOS group. The SOS mortality rate was 4/19 (21.1%). Univariate analyses revealed that Cy 200 mg/m2 conditioning (p = 0.035), classical Cy-ATG conditioning (p = 0.007), and horse ATG conditioning (p < 0.001) were significant risk factors for developing SOS. Multivariate analysis revealed that only horse ATG conditioning was a poor prognostic factor (HR = 3.484; 95% CI 1.226-9.904; p = 0.002). Rabbit ATG (HR 12.719; 95% CI 2.332-69.373; p = 0.003) and weight gain > 10% (HR 35.655; 95% CI 2.208-575.805; p = 0.012) were risk factors in the overall SOS group. Both rabbit ATG conditioning and weight gain of more than 10% were associated with poor overall survival with a median of 1.2 months (5Y survival rate, any risk factor vs. none: 74.6% vs. 0.0%; p < 0.001; Fig. 2) in the SOS group. In conclusion, SOS is a relatively rare (7.3%) but highly fatal (21.1%) acute complication of alloHSCT in AA, and the horse ATG conditioning regimen was a significant risk factor for developing SOS. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | BONE-MARROW-TRANSPLANTATION | - |
dc.subject | TOTAL-BODY IRRADIATION | - |
dc.subject | VENOOCCLUSIVE DISEASE | - |
dc.subject | PLASMINOGEN-ACTIVATOR | - |
dc.subject | CONDITIONING REGIMEN | - |
dc.subject | LIVER TOXICITY | - |
dc.subject | ORAL BUSULFAN | - |
dc.subject | CYCLOPHOSPHAMIDE | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | LEUKEMIA | - |
dc.title | Hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation in adult patients with idiopathic aplastic anemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Byung Soo | - |
dc.identifier.doi | 10.1016/j.leukres.2013.06.024 | - |
dc.identifier.scopusid | 2-s2.0-84883550974 | - |
dc.identifier.wosid | 000324099100014 | - |
dc.identifier.bibliographicCitation | LEUKEMIA RESEARCH, v.37, no.10, pp.1241 - 1247 | - |
dc.relation.isPartOf | LEUKEMIA RESEARCH | - |
dc.citation.title | LEUKEMIA RESEARCH | - |
dc.citation.volume | 37 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1241 | - |
dc.citation.endPage | 1247 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | TOTAL-BODY IRRADIATION | - |
dc.subject.keywordPlus | VENOOCCLUSIVE DISEASE | - |
dc.subject.keywordPlus | PLASMINOGEN-ACTIVATOR | - |
dc.subject.keywordPlus | CONDITIONING REGIMEN | - |
dc.subject.keywordPlus | LIVER TOXICITY | - |
dc.subject.keywordPlus | ORAL BUSULFAN | - |
dc.subject.keywordPlus | CYCLOPHOSPHAMIDE | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordAuthor | Sinusoidal obstruction syndrome | - |
dc.subject.keywordAuthor | Veno-occlusive disease | - |
dc.subject.keywordAuthor | Aplastic anemia | - |
dc.subject.keywordAuthor | Allogeneic hematopoietic stem cell transplantation | - |
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