Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Jung Ar | - |
dc.contributor.author | Chung, Jin Sil | - |
dc.contributor.author | Cho, Sang-Ho | - |
dc.contributor.author | Kim, Hyung Jung | - |
dc.contributor.author | Yoo, Young Do | - |
dc.date.accessioned | 2021-09-05T21:18:28Z | - |
dc.date.available | 2021-09-05T21:18:28Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-09-20 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102142 | - |
dc.description.abstract | Oxidant-mediated death of lung epithelial cells due to cigarette smoking plays an important role in pathogenesis in lung diseases such as idiopathic pulmonary fibrosis (IPF). However, the exact mechanism by which oxidants induce epithelial cell death is not fully understood. Reactive oxygen species (ROS) modulator 1 (Romo1) is localized in the mitochondria and mediates mitochondrial ROS production through complex III of the mitochondrial electron transport chain. Here, we show that Romo1 mediates mitochondrial ROS production and apoptosis induced by oxidative stress in lung epithelial cells. Hydrogen peroxide (H2O2) treatment increased Romo1 expression, and Romo1 knockdown suppressed the cellular ROS levels and cell death triggered by H2O2 treatment. In immunohistochemical staining of lung tissues from patients with IPF, Romo1 was mainly localized in hyperplastic alveolar and bronchial epithelial cells. Romo1 overexpression was detected in 14 of 18 patients with IPF. TUNEL-positive alveolar epithelial cells were also detected in most patients with IPF but not in normal controls. These findings suggest that Romo1 mediates apoptosis induced by oxidative stress in lung epithelial cells. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | CIGARETTE-SMOKE | - |
dc.subject | PULMONARY-FIBROSIS | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | ROS PRODUCTION | - |
dc.subject | PATHOGENESIS | - |
dc.subject | SUPEROXIDE | - |
dc.subject | ACTIVATION | - |
dc.subject | INDUCTION | - |
dc.subject | CERAMIDE | - |
dc.title | Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Young Do | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.07.012 | - |
dc.identifier.scopusid | 2-s2.0-84884282537 | - |
dc.identifier.wosid | 000325304900027 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.439, no.2, pp.315 - 320 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 439 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 315 | - |
dc.citation.endPage | 320 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | CIGARETTE-SMOKE | - |
dc.subject.keywordPlus | PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | ROS PRODUCTION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CERAMIDE | - |
dc.subject.keywordAuthor | Idiopathic pulmonary fibrosis | - |
dc.subject.keywordAuthor | Lung injury | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Romo1 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.