TNF-alpha-308G > A polymorphism is associated with suicide attempts in major depressive disorder
- Authors
- Kim, Yong-Ku; Hong, Jin-Pyo; Hwang, Jung-A.; Lee, Heon-Jeong; Yoon, Ho-Kyoung; Lee, Bun-Hee; Jung, Han-Yong; Hahn, Sang-Woo; Na, Kyoung-Sae
- Issue Date
- 5-9월-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Tumor necrosis factor-alpha; Interferon gamma; Interleukin-10; Suicide; Depression
- Citation
- JOURNAL OF AFFECTIVE DISORDERS, v.150, no.2, pp.668 - 672
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- JOURNAL OF AFFECTIVE DISORDERS
- Volume
- 150
- Number
- 2
- Start Page
- 668
- End Page
- 672
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102180
- DOI
- 10.1016/j.jad.2013.03.019
- ISSN
- 0165-0327
- Abstract
- Background: Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor alpha (TNF-alpha) -308G>A, interferon-gamma (IFN-gamma) +874A>T, and inlerleukin-10 (IL-10) -1082A>G are associated with increased risk for suicide attempts in MDD. Methods: Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square Lest was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results: The GG genotype of the TNF-alpha -308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR=2.630, 95% CI=1.206 to 5.734). IFN-gamma +874A>T and IL-10 -1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations: Limitations include a relatively small sample size and a cross-sectional design. Conclusions: TNF-alpha -308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha -308G>A influences suicide in MDD. (C) 2013 Elsevier B.V. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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