Association between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-05T21:58:46Z | - |
dc.date.available | 2021-09-05T21:58:46Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1470-3203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102221 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether the insertion (I) /deletion (D) polymorphism within intron 16 of angiotensin-converting enzyme (ACE) confers susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). Methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and SLE and LN. Results: A total of 1907 patients with SLE and 1842 controls in 18 comparative studies were included in this meta-analysis. The analysis showed a significant association between SLE and the DD genotype (recessive effect) of the ACE polymorphism (odds ratio [OR] 1.383, 95% confidence interval [CI] 1.065-1.797, p = 0.015). Stratification by ethnicity indicated a marginal association between the DD genotype and SLE in Europeans (OR 1.210, 95% CI 0.964-1.519, p = 0.099; I-2 = 0%). Meta-analysis also revealed a trend toward to an association between SLE and the ACE polymorphism using the allelic or additive models in Europeans. Furthermore, meta-analysis of the DD+ID genotype showed a significant association with LN (OR 0.582, 95% CI 0.425-0.797, p = 0.001; I-2 = 0%). Conclusion: This meta-analysis demonstrates a strong association between DD genotype and SLE in overall study and a marginal association between SLE and the ACE D/I polymorphism in Europeans, and suggests that this polymorphism might confer susceptibility to LN. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | ACE GENE | - |
dc.subject | DISEASE | - |
dc.subject | SLE | - |
dc.subject | NEPHROPATHY | - |
dc.subject | MORBIDITY | - |
dc.subject | THERAPY | - |
dc.title | Association between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1177/1470320312459979 | - |
dc.identifier.scopusid | 2-s2.0-84882957642 | - |
dc.identifier.wosid | 000323207100009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.14, no.3, pp.248 - 254 | - |
dc.relation.isPartOf | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.title | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 248 | - |
dc.citation.endPage | 254 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | ACE GENE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | MORBIDITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | angiotensin-converting enzyme | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | lupus nephritis | - |
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