Bone formation of middle ear cavity using biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 using animal model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.contributor.author | Choi, Kyung-Hee | - |
dc.contributor.author | Kim, Bo Hae | - |
dc.contributor.author | Lee, Eun Kyeung | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.date.accessioned | 2021-09-05T22:02:25Z | - |
dc.date.available | 2021-09-05T22:02:25Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 0165-5876 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102242 | - |
dc.description.abstract | Objective: The aim of the study was to analyze the value of Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) coated biphasic calcium phosphate (BCP) for the obliteration of middle ear bone defect after mastoid surgery. Methods: Twenty-four specific pathogen-free Sprague-Dawley rats were randomly assigned to the BCP group (n = 12) and BCP-ErhBMP-2 group (n = 12; in which BCP scaffold of the granular type was coated with ErhBMP-2). In both groups, BCP scaffold was used to surgically fill the middle ear bulla. New bone formation was evaluated by measuring bone density (%) after 4 and 8 weeks in all rats in both groups. Results: At 4 weeks, new bone was visible at the periphery and center of the middle ear cavity in both groups. In the BCP group, a moderate amount of fibrous tissue had infiltrated into the interspace of the scaffolds. New bone almost totally filled the interspace in the BCP-ErhBMP-2 group. At 8 weeks, copious new bone formation had occurred. Histometric measurements showed that bone density in the BCP group was smaller than in the BCP-ErhBMP-2 group at 4 weeks (25.10% and 38.43%, respectively; p < 0.05) and 8 weeks (25.54% and 34.18%, respectively; p < 0.05). Conclusions: New bone formation was greater in the presence of BCP-ErhBMP-2 scaffolds. ErhBMP-2 coated BCP scaffolds is a potentially useful material for middle ear obliteration after mastoidectomy. (C) 2013 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | MASTOID OBLITERATION | - |
dc.subject | HYDROXYAPATITE CEMENT | - |
dc.subject | CANAL WALL | - |
dc.subject | RECONSTRUCTION | - |
dc.subject | DELIVERY | - |
dc.subject | RHBMP-2 | - |
dc.subject | FLAP | - |
dc.title | Bone formation of middle ear cavity using biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 using animal model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.identifier.doi | 10.1016/j.ijporl.2013.05.035 | - |
dc.identifier.scopusid | 2-s2.0-84882620081 | - |
dc.identifier.wosid | 000324363400009 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, v.77, no.9, pp.1430 - 1433 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | - |
dc.citation.volume | 77 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1430 | - |
dc.citation.endPage | 1433 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | MASTOID OBLITERATION | - |
dc.subject.keywordPlus | HYDROXYAPATITE CEMENT | - |
dc.subject.keywordPlus | CANAL WALL | - |
dc.subject.keywordPlus | RECONSTRUCTION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordPlus | FLAP | - |
dc.subject.keywordAuthor | Otitis media | - |
dc.subject.keywordAuthor | Mastoid obliteration | - |
dc.subject.keywordAuthor | Scaffold | - |
dc.subject.keywordAuthor | Bone morphogenetic protein | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.