Association between CTLA-4 polymorphisms and susceptibility to Celiac disease: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Kim, Young Ho | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T22:06:12Z | - |
dc.date.available | 2021-09-05T22:06:12Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102265 | - |
dc.description.abstract | Objective: The study explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphisms confer susceptibility to Celiac disease (CD). Methods: A meta-analysis was conducted on the associations between the CTLA-4 CT60 A/G, +49 A/G, -318 C/T polymorphisms and CD using allele contrast, a recessive model, a dominant model, and homozygote contrast. Results: Thirteen separate comparison studies were considered in the meta-analysis consisting of 5072 patients with CD and 13,462 controls. All subjects were Europeans. Meta-analysis of the CTLA-4 CT60 A/G polymorphism showed an association between CD and the CTLA-4 CT60 G allele in all subjects [Odds ratio (OR) = 1.160, 95% Confidence interval (CI) = 1.104-1.219, p < 1.0 x 10(-9)). Meta-analysis using the recessive model also revealed an association between CD and the CTLA-4CT60 GG genotype (OR = 1.331, 95% CI = 1.093-1.620, p = 0.004). Furthermore, analyses using the dominant model and homozygote contrast showed the same pattern as that shown by the CTLA-4CT60 G allele. Meta-analysis of the CTLA-4 +49 A/G polymorphism showed no association between CD and the CTLA-4 +49 G allele in all subjects (OR = 0.992, 95% CI = 0.872-1.129, p = 0.907). Meta-analysis using the recessive, dominant model, and homozygote contrast showed the same pattern as that shown by the CTLA-4 +49 Gallele. Meta-analysis of the CTLA-4 -318 C/T polymorphism showed no association between CD and the CTLA-4 -318 T allele in all subjects (OR = 1.018, 95% Cl = 0.813-1.275, p = 0.877). Conclusions: The CTLA-4 CT60 A/G polymorphism was associated with CD susceptibility, but no association was found between CTLA-4 +49 A/G and -318 C/T polymorphisms and CD in Europeans. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | AUTOIMMUNE-DISEASES | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | COMMON | - |
dc.subject | POPULATION | - |
dc.subject | REGION | - |
dc.subject | A/G | - |
dc.subject | VARIANTS | - |
dc.subject | TRIALS | - |
dc.title | Association between CTLA-4 polymorphisms and susceptibility to Celiac disease: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1016/j.humimm.2013.05.014 | - |
dc.identifier.scopusid | 2-s2.0-84880926438 | - |
dc.identifier.wosid | 000322939400024 | - |
dc.identifier.bibliographicCitation | HUMAN IMMUNOLOGY, v.74, no.9, pp.1214 - 1218 | - |
dc.relation.isPartOf | HUMAN IMMUNOLOGY | - |
dc.citation.title | HUMAN IMMUNOLOGY | - |
dc.citation.volume | 74 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1214 | - |
dc.citation.endPage | 1218 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASES | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | COMMON | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | A/G | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | TRIALS | - |
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