Platelet-activating factor receptor knockout mice are protected from MPTP-induced dopaminergic degeneration
DC Field | Value | Language |
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dc.contributor.author | Kim, Beom Keun | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Dang, Duy-Khanh | - |
dc.contributor.author | Jung, Bae-Dong | - |
dc.contributor.author | Park, Dae-Hun | - |
dc.contributor.author | Wie, Myung Bok | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.contributor.author | Shimizu, Takao | - |
dc.contributor.author | Nabeshima, Toshitaka | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.date.accessioned | 2021-09-05T22:13:00Z | - |
dc.date.available | 2021-09-05T22:13:00Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 0197-0186 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102306 | - |
dc.description.abstract | Platelet-activating factor (PAF), a potent mediator of inflammatory and immune responses, plays various roles in neuronal functions. However, little is known about the role of PAF/platelet-activating factor receptor (PAF-R) in Parkinson's disease. Treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) resulted in significant increases in PAP species in the striatum of wild-type mice. These increases paralleled PAF-R gene expression in wild-type mice. Although nuclear factor kappa B (NF-kappa B) DNA-binding activity was increased significantly in MPTP-treated wild-type mice, this increase was not significant in PAF-R antagonist ginkgolide B (GB)-treated mice or PAF-R knockout (PAP-R-/-) mice. Pyrrolidine dithiocarbamate (PDTC), an NF-kappa B inhibitor, significantly ameliorated the dopaminergic deficits induced by MPTP in wild-type mice. MPTP treatment significantly increased oxidative damage, the immunoreactivity of ionized calcium binding adaptor molecule 1 (Iba-1)-positive microglial cells, and microglial differentiation of the M1 type in the striatum of wild-type mice. Consistently, PDTC significantly attenuated MPTP-induced behavioral impairments in wild-type mice. However, dopaminergic deficits, oxidative damage, reactive microglial cells, and behavioral impairments induced by MPTP were not significantly observed in GB-treated mice or PAP-R-/- mice. PDTC did not significantly alter the attenuations evident in MPTP-treated PAF-R-/- mice, indicating that NF-kappa B is a critical target for neurotoxic modulation of PAF-R. We propose for the first time that PAF/PAF-R can mediate dopaminergic degeneration via an NF-kappa B-dependent signaling process. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | PARKINSONS-DISEASE | - |
dc.subject | PAF RECEPTOR | - |
dc.subject | MICROGLIAL ACTIVATION | - |
dc.subject | RAT HIPPOCAMPUS | - |
dc.subject | MOUSE MODEL | - |
dc.subject | IN-VIVO | - |
dc.subject | NEURONS | - |
dc.subject | EXPRESSION | - |
dc.subject | DEXTROMETHORPHAN | - |
dc.title | Platelet-activating factor receptor knockout mice are protected from MPTP-induced dopaminergic degeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Won-Ki | - |
dc.identifier.doi | 10.1016/j.neuint.2013.05.010 | - |
dc.identifier.scopusid | 2-s2.0-84879208877 | - |
dc.identifier.wosid | 000323590300001 | - |
dc.identifier.bibliographicCitation | NEUROCHEMISTRY INTERNATIONAL, v.63, no.3, pp.121 - 132 | - |
dc.relation.isPartOf | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.title | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.volume | 63 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 121 | - |
dc.citation.endPage | 132 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | PAF RECEPTOR | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | RAT HIPPOCAMPUS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DEXTROMETHORPHAN | - |
dc.subject.keywordAuthor | Platelet-activating factor receptor | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Striatum | - |
dc.subject.keywordAuthor | Dopamine | - |
dc.subject.keywordAuthor | Nuclear factor kappa B | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Oxidative damage | - |
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