Effect of Chelators on the Pharmacokinetics of Tc-99m-Labeled Imaging Agents for the Prostate-Specific Membrane Antigen (PSMA)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Banerjee, Sangeeta Ray | - |
dc.contributor.author | Pullambhatla, Mrudula | - |
dc.contributor.author | Foss, Catherine A. | - |
dc.contributor.author | Falk, Alexander | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Nimmagadda, Sridhar | - |
dc.contributor.author | Mease, Ronnie C. | - |
dc.contributor.author | Pomper, Martin G. | - |
dc.date.accessioned | 2021-09-05T22:56:13Z | - |
dc.date.available | 2021-09-05T22:56:13Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08-08 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102469 | - |
dc.description.abstract | Technetium-99m, the most commonly used radionuclide in nuclear medicine, can be attached to biologically important molecules through a variety of chelating agents, the choice of which depends upon the imaging application. The prostate-specific membrane antigen (PSMA) is increasingly recognized as an important target for imaging and therapy of prostate cancer (PCa). Three different Tc-99m-labeling methods were employed to investigate the effect of the chelator on the biodistribution and PCa tumor uptake profiles of 12 new urea-based PSMA-targeted radiotracers. This series includes hydrophilic ligands for radiolabeling with the [Tc-99m(CO)(3)](+) core (L8-L10), traditional NxSy-based chelating agents with varying charge and polarity for the Tc-99m-oxo core (L11-L18), and a Tc-99m-organohydrazine-labeled radioligand (L19). Tc-99m(I)-Tricarbonyl-labeled [Tc-99m]L8 produced the highest PSMA+ PC3 PIP to PSMA- PC3 flu tumor ratios and demonstrated the lowest retention in normal tissues including kidney after 2 h. These results suggest that choice of chelator is an important pharmacokinetic consideration in the development of Tc-99m-labeled radiopharmaceuticals targeting PSMA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | LINKED ACIDIC DIPEPTIDASE | - |
dc.subject | SOLID-PHASE SYNTHESIS | - |
dc.subject | GLUTAMATE CARBOXYPEPTIDASES | - |
dc.subject | PRECLINICAL EVALUATION | - |
dc.subject | BIFUNCTIONAL CHELATOR | - |
dc.subject | IN-VITRO | - |
dc.subject | CANCER | - |
dc.subject | TC-99M | - |
dc.subject | EXPRESSION | - |
dc.subject | INHIBITOR | - |
dc.title | Effect of Chelators on the Pharmacokinetics of Tc-99m-Labeled Imaging Agents for the Prostate-Specific Membrane Antigen (PSMA) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.1021/jm400823w | - |
dc.identifier.scopusid | 2-s2.0-84881429638 | - |
dc.identifier.wosid | 000323082400009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL CHEMISTRY, v.56, no.15, pp.6108 - 6121 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 56 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 6108 | - |
dc.citation.endPage | 6121 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | LINKED ACIDIC DIPEPTIDASE | - |
dc.subject.keywordPlus | SOLID-PHASE SYNTHESIS | - |
dc.subject.keywordPlus | GLUTAMATE CARBOXYPEPTIDASES | - |
dc.subject.keywordPlus | PRECLINICAL EVALUATION | - |
dc.subject.keywordPlus | BIFUNCTIONAL CHELATOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TC-99M | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INHIBITOR | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.