Obstructive sleep apnea as a risk factor for silent cerebral infarction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Eo Rin | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Seo, Hyung Suk | - |
dc.contributor.author | Suh, Sooyeon | - |
dc.contributor.author | Lee, Seung Ku | - |
dc.contributor.author | Shin, Chol | - |
dc.date.accessioned | 2021-09-05T23:03:24Z | - |
dc.date.available | 2021-09-05T23:03:24Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0962-1105 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102499 | - |
dc.description.abstract | Previous studies have suggested that obstructive sleep apnea (OSA) may be a risk factor for stroke. In this study, we assessed that OSA is an independent risk factor of silent cerebral infarction (SCI) in the general population, and in a non-obese population. This study recruited a total of 746 participants (252 men and 494 women) aged 50-79 years as part of the Korean Genome and Epidemiology Study (KoGES); they underwent polysomnography, brain magnetic resonance imaging and health screening examinations. SCI was assessed by subtypes and brain regions, and lacunar infarction represented lesions <15 mm in size in the penetrating arteries. Moderate-severe OSA was determined by apnea-hypopnea index >= 15. The results indicated that 12.06% had moderate-severe OSA, 7.64% of participants had SCI and 4.96% had lacunar infarction. Moderate-severe OSA was associated positively with SCI [odds ratio (OR): 2.44, 95% confidence interval (CI): 1.03-5.80] and lacunar infarction (OR: 3.48, 95% CI: 1.31-9.23) in the age >= 65-year group compared with those with non-OSA. Additionally, in the basal ganglia, OSA was associated with an increase in the odds for SCI and lacunar infarction in all age groups, and especially in the >= 65-year age group. In the non-obese participants, OSA was also associated positively with SCI in the >= 65-year age group, lacunar infarction in all age groups, and especially in the >= 65-year age group. There was also a positive association with the basal ganglia. Moderate-severe OSA was associated positively with SCI and lacunar infarction in elderly participants. Treatment of OSA may reduce new first-time cerebrovascular events and recurrences. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | BRAIN INFARCTION | - |
dc.subject | ISCHEMIC-STROKE | - |
dc.subject | PREVALENCE | - |
dc.subject | DISEASE | - |
dc.subject | POPULATION | - |
dc.title | Obstructive sleep apnea as a risk factor for silent cerebral infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Hyung Suk | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.1111/jsr.12034 | - |
dc.identifier.scopusid | 2-s2.0-84880509686 | - |
dc.identifier.wosid | 000321773200013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SLEEP RESEARCH, v.22, no.4, pp.452 - 458 | - |
dc.relation.isPartOf | JOURNAL OF SLEEP RESEARCH | - |
dc.citation.title | JOURNAL OF SLEEP RESEARCH | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 452 | - |
dc.citation.endPage | 458 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | BRAIN INFARCTION | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | basal ganglia | - |
dc.subject.keywordAuthor | lacunar infarction | - |
dc.subject.keywordAuthor | obstructive sleep apnea | - |
dc.subject.keywordAuthor | risk factors | - |
dc.subject.keywordAuthor | silent cerebral infarction | - |
dc.subject.keywordAuthor | stroke | - |
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