Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs
DC Field | Value | Language |
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dc.contributor.author | Kim, J. M. | - |
dc.contributor.author | Ahn, J. H. | - |
dc.contributor.author | Lim, K. S. | - |
dc.contributor.author | Lee, E. A. | - |
dc.contributor.author | Chun, T. | - |
dc.contributor.author | Hong, K. C. | - |
dc.date.accessioned | 2021-09-05T23:05:59Z | - |
dc.date.available | 2021-09-05T23:05:59Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0268-9146 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102514 | - |
dc.description.abstract | A high level of androstenone in porcine adipose tissue is a major factor contributing to boar taint. Porcine hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1 (3 beta-HSD, also known as HSD3b1) plays a key role in the hepatic metabolism that catalyzes androstenone to b-androstenol. Therefore, 3 beta-HSD is a candidate gene for boar taint. This study aimed to investigate functional 3 beta-HSD polymorphisms in Duroc pigs. We found eight single nucleotide polymorphisms (SNPs) in the full-length porcine 3 beta-HSD. Four of the SNPs had restriction enzyme sites, and we genotyped them in 147 uncastrated male Duroc pigs using a polymerase chain reaction-restriction fragment length polymorphism method. Pigs with the GG genotype at the g. 165262G>A locus (SNP5) had significantly lower androstenone levels than did those with other genotypes (P = 0.030). SNP5 also was associated with differences in 3 beta-HSD mRNA levels: pigs with the GG genotype had higher levels than those with other genotypes (P = 0.019). The SNP5 polymorphism could affect the hepatic catabolism of androstenone and consequently impact androstenone accumulation in the adipose tissue. Therefore, SNP5 in the 3 beta-HSD of Duroc pigs could be a useful selective marker for decreasing boar taint. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | - |
dc.subject | BOAR TAINT | - |
dc.subject | PPARGC1A GENE | - |
dc.subject | MEAT QUALITY | - |
dc.subject | SKATOLE | - |
dc.subject | METABOLISM | - |
dc.subject | SEQUENCE | - |
dc.subject | HORMONES | - |
dc.subject | PORK | - |
dc.title | Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, T. | - |
dc.contributor.affiliatedAuthor | Hong, K. C. | - |
dc.identifier.doi | 10.1111/age.12041 | - |
dc.identifier.scopusid | 2-s2.0-84883444988 | - |
dc.identifier.wosid | 000323724300013 | - |
dc.identifier.bibliographicCitation | ANIMAL GENETICS, v.44, no.5, pp.592 - 595 | - |
dc.relation.isPartOf | ANIMAL GENETICS | - |
dc.citation.title | ANIMAL GENETICS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 592 | - |
dc.citation.endPage | 595 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Dairy & Animal Science | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | - |
dc.subject.keywordPlus | BOAR TAINT | - |
dc.subject.keywordPlus | PPARGC1A GENE | - |
dc.subject.keywordPlus | MEAT QUALITY | - |
dc.subject.keywordPlus | SKATOLE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | HORMONES | - |
dc.subject.keywordPlus | PORK | - |
dc.subject.keywordAuthor | 3-hydroxysteroid dehydrogenase | - |
dc.subject.keywordAuthor | boar taint | - |
dc.subject.keywordAuthor | single nucleotide polymorphism | - |
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