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Dysregulation of KSHV Replication by Extracts from Carthamus tinctorius L.

Authors
Lee, HanCho, HyosunSon, MyoungkiSung, Gi-HoLee, TaehoLee, Sang-WonJung, Yong WooShin, Yu SuKang, Hyojeung
Issue Date
8월-2013
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Keywords
Carthamus tinctorius L.; Kaposi' s sarcoma-associated herpesvirus; extracts; latency; lytic reactivation
Citation
JOURNAL OF MICROBIOLOGY, v.51, no.4, pp.490 - 498
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MICROBIOLOGY
Volume
51
Number
4
Start Page
490
End Page
498
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/102543
DOI
10.1007/s12275-013-3282-7
ISSN
1225-8873
Abstract
Carthamus tinctorius L. (CT) is traditionally used to reduce ailments from diseases of the musculoskeletal system and connective tissue and diseases of blood circulation and the cardiovascular system. Flower extracts from CT are known to have antibacterial activity, anti-inflammatory activity, and to inhibit tumor promotion in mouse skin carcinogenesis. In order to discover new antiviral agents from CT extracts, we tested whether CT extracts contain antiviral activity against gammaherpesvirus infection. This study demonstrated that treatment with CT extracts disrupted KSHV latency in the viral-infected host cells, iSLK-BAC16. n-Hexane and EtOH fractions of CT extracts critically affected at least two stages of the KHSV life-cycle by abnormally inducing KSHV lytic reactivation and by severely preventing KSHV virion release from the viral host cells. In addition to the effects on KSHV itself, CT extract treatments induced cellular modifications by dysregulating cell-cycle and producing strong cytotoxicity. This study demonstrated for the first time that CT extracts have antiviral activities that could be applied to development of new anti-gammaherpesviral agents.
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약학대학 (약학과)
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