Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing Three 2nd-Generation Drug-Eluting Stents in Real-World Practice" (CHOICE trial)
- Authors
- Youn, Young Jin; Lee, Jun-Won; Ahn, Sung Gyun; Lee, Seung-Hwan; Choi, Hyun Hee; Choi, Hyunmin; Choi, Cheol Ung; Lee, Jin Bae; Cho, Jang Hyun; Kang, Tae Soo; Cho, Byung Ryul; Cha, Kwang Soo; Kim, Moo Hyun; Hyon, Min Su; Cheong, Sang-Sig; Lim, Do-Sun; Han, Kyoo Rok; Jeong, Myung Ho; Park, Keum Soo; Yoon, Junghan
- Issue Date
- 8월-2013
- Publisher
- MOSBY-ELSEVIER
- Citation
- AMERICAN HEART JOURNAL, v.166, no.2, pp.224 - 229
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN HEART JOURNAL
- Volume
- 166
- Number
- 2
- Start Page
- 224
- End Page
- 229
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102554
- DOI
- 10.1016/j.ahj.2013.04.014
- ISSN
- 0002-8703
- Abstract
- Background The second-generation drug-eluting stents (DES) have shown superiority in many studies relating to safety and efficacy when compared with the first-generation DES. However, it is unclear whether there are differences in efficacy and safety among the second-generation DES after long-term follow-up. Methods This multicenter, prospective, randomized, open-labeled trial will directly compare the efficacy and safety among the patients treated with either everolimus-eluting stent (EES), zotarolimus-eluting stent with biolinx polymer (ZES-R), or biolimus-eluting stent (BES) with minimal exclusion criteria. The primary end point is a patient-oriented composite consisted of cardiac death, myocardial infarction not clearly attributable to a nontarget vessel and clinically indicated target lesion revascularization at 24-month clinical follow-up post-index procedure. With the hypothesis that "BES is non-inferior to EES" or "BES is non-inferior to ZES-R" in primary end point, approximately 2,600 patients will be assigned to one of the types of stents using a web-based randomization system. Conclusions The CHOICE trial will directly compare the efficacy and safety of EES, ZES-R, and BES in everyday clinical practice for long-term follow-up.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.