Prx I Suppresses K-ras-Driven Lung Tumorigenesis by Opposing Redox-Sensitive ERK/Cyclin D1 Pathway
DC Field | Value | Language |
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dc.contributor.author | Park, Young-Ho | - |
dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Lee, Bo-Kyoung | - |
dc.contributor.author | Kim, Hyun-Sun | - |
dc.contributor.author | Song, In-Sung | - |
dc.contributor.author | Shin, Hye-Jun | - |
dc.contributor.author | Han, Ying-Hao | - |
dc.contributor.author | Chang, Kyu-Tae | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Lee, Dong-Seok | - |
dc.contributor.author | Kim, Yeul-Hong | - |
dc.contributor.author | Choi, Chang-Min | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Yu, Dae-Yeul | - |
dc.date.accessioned | 2021-09-05T23:19:27Z | - |
dc.date.available | 2021-09-05T23:19:27Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1523-0864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102596 | - |
dc.description.abstract | Aims: Coupled responses of mutated K-ras and oxidative stress are often an important etiological factor in non-small-cell lung cancer (NSCLC). However, relatively few studies have examined the control mechanism of oxidative stress in oncogenic K-ras-driven NSCLC progression. Here, we studied whether the redox signaling pathway governed by peroxiredoxin I (Prx I) is involved in K-ras(G12D)-mediated lung adenocarcinogenesis. Results: Using human-lung adenocarcinoma tissues and lung-specific K-ras(G12D)-transgenic mice, we found that Prx I was significantly up-regulated in the tumor regions via activation of nuclear erythroid 2-related factor 2 (Nrf2) transcription. Interestingly, the increased reactive oxygen species (ROS) by null mutation of Prx I greatly promoted K-ras(G12D)-driven lung tumorigenesis in number and size, which appeared to require the activation of the ROS-dependent extracellular signal-regulated kinase (ERK)/cyclin D1 pathway. Innovation: Taken together, these results suggest that Prx I functions as an Nrf2-dependently inducible tumor suppressant in K-ras-driven lung adenocarcinogenesis by opposing ROS/ERK/cyclin D1 pathway activation. Conclusion: These findings provide a better understanding of oxidative stress-mediated lung tumorigenesis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | CANCER-CELLS | - |
dc.subject | CYCLIN D1 | - |
dc.subject | ANTIOXIDANT DEFENSE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PEROXIREDOXIN-I | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | STEM-CELLS | - |
dc.subject | C-MYC | - |
dc.subject | EXPRESSION | - |
dc.title | Prx I Suppresses K-ras-Driven Lung Tumorigenesis by Opposing Redox-Sensitive ERK/Cyclin D1 Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yeul-Hong | - |
dc.identifier.doi | 10.1089/ars.2011.4421 | - |
dc.identifier.scopusid | 2-s2.0-84877597805 | - |
dc.identifier.wosid | 000321552500004 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS & REDOX SIGNALING, v.19, no.5, pp.482 - 496 | - |
dc.relation.isPartOf | ANTIOXIDANTS & REDOX SIGNALING | - |
dc.citation.title | ANTIOXIDANTS & REDOX SIGNALING | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 482 | - |
dc.citation.endPage | 496 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | ANTIOXIDANT DEFENSE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PEROXIREDOXIN-I | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | EXPRESSION | - |
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