Toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms and periodontitis susceptibility: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T23:24:03Z | - |
dc.date.available | 2021-09-05T23:24:03Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102624 | - |
dc.description.abstract | The aim of this study was to determine whether the toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms confers susceptibility to periodontitis in ethnically different populations. A literature search using PubMed and Embase provided the data to conduct a meta-analysis on the associations between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-1 -1607 G1/G2 and MMP-9 -1562 C/T polymorphisms and periodontitis. A total of 32 studies (14 on TLR polymorphisms and 18 on MMP polymorphisms) were considered in the meta-analysis. The meta-analysis showed no association between periodontitis and the TLR2 753Arg allele (Odds ratio [OR] = 0.962, 95 % confidence interval [CI] = 0.662-1.400, p = 0.841). Meta-analysis of the TLR4 Asp299Gly and Thr399Ile polymorphisms showed no association between periodontitis and the TLR4 299Asp allele in all study subjects (OR = 0.984, 95 % CI = 0.761-1.271, p = 0.900; OR = 1.030, 95 % CI = 0.748-1.418, p = 0.854). Meta-analysis showed an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians (OR = 3.778, 95 % CI = 1.210-11.80, p = 0.022). Meta-analysis containing only studies in Hardy-Weinberg equilibrium revealed no association between chronic periodontitis and the MMP-9 -1562TT genotype (OR = 0.638, 95 % CI = 0.265-1.533, p = 0.315). This meta-analysis demonstrates a lack of association between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-9 -1562 C/T polymorphisms and periodontitis, but shows an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | TOLL-LIKE-RECEPTOR-4 GENE POLYMORPHISMS | - |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISMS | - |
dc.subject | PROMOTER POLYMORPHISMS | - |
dc.subject | ASSOCIATION | - |
dc.subject | SEVERITY | - |
dc.subject | RISK | - |
dc.subject | DISEASE | - |
dc.subject | CD14 | - |
dc.subject | RECOGNITION | - |
dc.subject | POPULATION | - |
dc.title | Toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms and periodontitis susceptibility: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s11033-013-2616-1 | - |
dc.identifier.scopusid | 2-s2.0-84881125420 | - |
dc.identifier.wosid | 000322392300053 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.40, no.8, pp.5129 - 5141 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 40 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5129 | - |
dc.citation.endPage | 5141 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | TOLL-LIKE-RECEPTOR-4 GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CD14 | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | MMP | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Periodontitis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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